Iris Publishers- Open access journal of Urology & Nephrology | Hypercapnia in Hemodialysis (HD)

Authored by  David Tovbin

Acute intra-dialytic exacerbation of hypercapnia in hemodialysis (HD) patient has been initially reported 18 years ago [1]. Subsequent similar case was reported few years later [2]. Common features of both patients were morbid obesity, a previously stable HD sessions and an acute respiratory infection at time of hypercapnia [1,2]. HD patients with decreased ventilation reserve, due to morbid obesity with or without obstructive sleep apnea (OSA) and/or obesity hypoventilation syndrome (OHS) as well as chronic obstructive pulmonary disease (COPD), are at increased risk. COPD is common among HD patients but frequently under-diagnosed [3]. Most COPD patients do well during HD with only mild- moderate pco₂ increases and slightly decreased pH as compared to non-COPD chronic HD patients [2,4]. However, acute pulmonary congestion or infection or gradual but significant deterioration in respiratory state, may induce hypercapnia with intradialytic exacerbation, hypercapnic encephalopathy and respiratory arrest [1,2,5]. A proposed mechanism is that tissue hypoxia due to hypoxemia and/ or low tissue perfusion as in sepsis and/or shock increase intradialytic acid generation, bicarbonate buffering and production of co₂, which cannot be exhaled at those states [1,2]. Some patients with severe COPD or OHS have baseline chronic severe hypercapnia and need the special measures which will be described below when starting hemodialysis. Symptoms of hypercapnic encephalopathy are correlated stronger with the changes in cerebrospinal pH induced by rapid diffusion of co₂, than with those of arterial pH and/or Pco₂. Both hypoxemia and on the other hand uncontrolled oxygen therapy with high inspiratory oxygen fractions (FiO2), which further decrease respiratory drive, have deleterious effects [5]. Nowadays, morbid obesity and associated obstructive sleep apnea (OSA) and possibly obesity hypoventilation syndrome (OHS) are common in the general population and even more in the population at risk for reaching HD [6-8]. Non-invasive positive pressure ventilation (NIPPV) such as continuous positive airway pressure (CPAP) and bi-level positive airway pressure (BiPAP) are nowadays commonly used in hypercapnic patients [5,9,10]. In the 2 case reports and in our experience with similar patients, BiPAP prevented intra-dialytic exacerbation of hypercapnia and possibly respiratory arrest [1,2]. In recent years, new interest was raised to HD dialysate bicarbonate concentration. After standardizing to inflammation malnutrition complex and comorbidities midweek pre-dialysis serum bicarbonate level was recommended as >22 mEq/L [11]. As higher dialysate bicarbonate concentration became more prevalent, a large observation cohort study demonstrated that high dialysate bicarbonate concentration was associated with worse outcome especially in the more acidotic patients.

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