Could Abnormal Distribution of Interstitial Cells of Cajal be Involved in Gastrointestinal Disorders in Patients with Parkinson’s Disease? - Neurology & Neuroscience

Parkinson’s disease (PD) is a common degenerative disease of  the nervous system in elderly   people. The main clinical manifestations are tremor and rigidity. In addition to the typical motor  symptoms, PD patients also have a higher incidence of gastrointestinal disorders, of which   constipation is the most common, with a foreign incidence of 67% [1], the incidence in domestic of  more than 50% [2]. Interstitial cells of Cajal (ICC) plays an important role in gastrointestinal motility as a pacemaker and transduction agent of gastrointestinal rhythmic electrical activity. To date, studies on the pathogenesis of PD gastrointestinal disorders have not involved the ICC pathway. In this study, we used anti-C-kit immuno histochemistry to observe  the distribution of ICCs in the intestinal tract of PD patients, so as to explore the role of ICCs in the gastrointestinal dysfunction of PD.

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