Non-Alcohol Fatty Liver Disease Goes Beyond the Liver (SJGH) - Iris Publishers
Non-Alcohol Fatty Liver Disease Goes Beyond the Liver (SJGH) - Iris Publishers
The liver is a multitasking organ with a large reserve
capacity. It plays a crucial role in metabolic homeostasis. Progressive
steatosis will compromise different liver functions and can lead to
severe organ dysfunction when the functional demand is increased as for
example in sepsis. In physiological situations, the functional volume of
the liver is adapted to body need. The liver enlarges when the capacity
of hepatocytes is stressed like for example in progressive steatosis.
In non-alcohol fatty liver disease (NAFLD) fat accumulation is greater
than 5% in combination with well-defined alcohol intake (men a maximum
of 20 grams and women 10 grams ethanol per day). To date, NAFLD is the
new challenge as HCV infections will be eradicated with the effective
drugs that have been developed over the years. About 25% of the world
population [1] is somewhere in the spectrum of: simple steatosis,
non-alcoholic steatohepatitis (NASH), NASH with fibrosis progressing to
severe complicated liver disease and hepatocellular carcinoma (HCC).
To read more...Peer reviewed Journals of Gastroenterology & Hepatology
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