Non-Alcohol Fatty Liver Disease Goes Beyond the Liver (SJGH) - Iris Publishers

Non-Alcohol Fatty Liver Disease Goes Beyond the Liver (SJGH) - Iris Publishers

The liver is a multitasking organ with a large reserve capacity. It plays a crucial role in metabolic homeostasis. Progressive steatosis will compromise different liver functions and can lead to severe organ dysfunction when the functional demand is increased as for example in sepsis. In physiological situations, the functional volume of the liver is adapted to body need. The liver enlarges when the capacity of hepatocytes is stressed like for example in progressive steatosis. In non-alcohol fatty liver disease (NAFLD) fat accumulation is greater than 5% in combination with well-defined alcohol intake (men a maximum of 20 grams and women 10 grams ethanol per day). To date, NAFLD is the new challenge as HCV infections will be eradicated with the effective drugs that have been developed over the years. About 25% of the world population [1] is somewhere in the spectrum of: simple steatosis, non-alcoholic steatohepatitis (NASH), NASH with fibrosis progressing to severe complicated liver disease and hepatocellular carcinoma (HCC).

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