Iris Publishers- Open access Journal of Agriculture and Soil Science | Chronic Exposure and the Risk of Building
Antibiotic Resistance in Rural Communities of
the Developing World
Authored by Mark Coyne
Antibiotic resistance is a global issue, not least the question if
resistance is intrinsic, acquired, or adaptive. The current scenario
demands investigations to detect resistance in environments from the
urban/rural nexus. The complexity of antibiotic resistance
in the environment is linked with the characteristics of recipient
compartments in various environmental systems. Much research
focuses on resistance in point sources (hotspots) of exposure, but after
release the risk of antibiotics affecting humans is quite
complex. Dispersion, dilution, and concentration reduction are part of
the natural cycle required to examine the fate of antibiotics in
the environment. Antibiotic residues at any stage threaten public health
no matter if they cause acute exposure or because of much
lower concentrations persisting in sediments, soils, irrigation waters,
groundwater, aerosols, and produce where they may reflect
chronic exposure. In either case, human exposure is undeniable with
differential impact. In view of local constraints and unintended
feedback we propose a research agenda to enhance understanding the
future of exposure intensity and the fate and synergistic
effect of antibiotics released into the environment in developing
resistance. We advocate the need to investigate sub-lethal antibiotic
concentrations and human populations aimed at limiting the acute and
chronic public exposure to antibiotic residues and resistant
microbes from soil and water among occupational groups and rural
population inhabiting resource-limited settings. The benefits of antibiotic use cannot be overemphasized; they
certainly outweigh the harm associated with their side effects.
However, when antibiotics are abused or overused, that harm
increases manifold with no benefit. Global antibiotic production for human use is a $40 billion-ayear
industry. Approximately 250 to 300 tons year of antibiotics
are used in human medicine and a much greater amount of
antibiotics are produced for livestock and aquaculture. To fulfill
ever increasing human demands, huge amounts of antibiotics are
produced worldwide, with projections for additionally expanded
production in the future [1]. It is estimated that global antibiotic
use will rise to 105,596 tons year–1 in 2030, with China the
largest consumer followed by the US, Brazil, Mexico, and India [2].
This increase reflects their broadened use for treating genuine
contamination identified with human well-being and welfare, and
for advancing and developing disease aversion in domesticated
animals. In particular, low- and middle-income countries showed
increased antibiotic use between 2000 and 2015 (+39%) which
suggests an alarming projection for a 200% rise globally by 2030.
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