Authored by L Nefyodov
The aim of our research is the formulation of methodology
creation for practical application of the regulatory action of
endogenous (physiological) concentrations of separate amino acids
or their pathogenetically justified compositions [1-4]. Changes
in amino acid pool in liquids and their tissues fund of oncology
patients specifically characterize development of cancer and
largely induced by metabolic competition between the tumor and
the tumor carrier [5-10]. Correction of the intermediate metabolic
changes in cancer can be reached by the use of certain amino acids
or their combinations. Based on the positions of metabolomics, the
free amino acid pool in biological fluids and tissues is regarded as
a single information unit which is a kind of “a chemical projection”
of the genome, the proteome realized through this approach not
only develops ideas about the pool of amino acids as a dynamical
system-generated supply of them from outside, but also due to
endogenous synthesis, transport, degradation and excretion and
allows the identification of “key points” in intermediate metabolic
equilibrium shift that may reflect ratios at the individual levels
of endogenous amino acids and related species (metabolicallyrelated)
compounds to achieve “metabolic comfort” [11-15].
On the basis of the experimental data we suggest that the
differences discovered in certain amino acids concentrations in
fluids and tissues are criteria in early diagnostics as in estimation
of the efficacy of specific cancer treatment. Our clinical studies
on biological fluids and tumors more than 1400 patients with
cancer depending on the location and stage of the process showed
significant changes in physiological concentrations of amino acids
which either directly or indirectly regulate processes of antitumor
response, oncogenesis, immunogenesis and apoptosis were shown
[16-18]. The creation methodology of pathogenetic compositions of
amino acids and their derivatives on the basis of their physiological
concentration for practical application of their regulatory effects in
oncology was discussed.
None.
No conflict of interest.
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