Friday, March 20, 2020

Iris Publishers- Open access Journal of Anaesthesia & Surgery | Neutrophil Extracellular Traps and Acute Pancreatitis

https://irispublishers.com/asoaj/images/irispublishers-openaccess-anaesthesia-surgery.ID.000508.G001.png


Authored by Raed Madhi*


Introduction

Acute pancreatitis (AP) is an acute inflammatory process of pancreatic gland that characterized by trypsinogen activation of intra acinar cells with inflammatory response can be extended to remote organs [1]. AP has been encountered in many countries with increased incidence [2,3]. In fact, the clinical manifestations of AP are variable and range from mild, with self-limiting abdominal disturbance and may go away without treatment, to severe cases that can cause life-threatening complications [4]. Normally, the complications that associated with mild case may recover within couple of days [5]. In contrast, severe case of AP can develop a local necrosis and systemic inflammation that can present in 20- 30% of patients and associated with up to 40% of mortality rate [6]. Although many studies have been tried to investigate a specific therapy of AP, however, so far it is largely limited to supportive therapies. Subsequently, management of patients with AP poses this problem a great challenge to clinicians. Therefore, it is suggested that understanding the pathophysiological mechanism of AP might be a key step in treatment this disease.
Having established that trypsinogen activation, inflammation and impaired microvascular perfusion are merged components in pathophysiology of AP [7,8]. It is well known that activation of trypsinogen appears to be initiated in the early step which can result in auto-digestion of pancreatic tissue. Indeed, leukocytes migration and recruitment have been shown to be a hallmark of inflammation and previous studies have implicated leukocytes in development of AP [9,10].

Role of Neutrphil in AP

Neutrophils are most abundant type of granulocytes and represent the first defense line of host immune response [11]. These cells are originally generated by bone marrow stem cells. Neutrophils have short live and characterized by their ability to leak from circulation out into damaged tissue [12]. During inflammation of AP, it has been observed that chemoattractant can be released into circulation and can cause neutrophils rolling and migration into pancreatic tiusse [13]. For example, previous studies have found that inflamed pancreas can release chemokines, such as CXCL1 and CXCL2 that direct the neutrophils to site of inflammation [14,15]. CXCR2 is a receptor expressed on murine neutrophil and has high affinity for CXCL1 and CXCL2 [16,17]. This receptor has observed to be a critical for neutrophil infiltration in the pancreas [18].
Furthermore, it has been observed that P-selectin has a key role in neutrophil rolling and recruitment in severe pancreatitis [19]. Indeed, a previous study has demonstrated that targeting P-selectin showed a significant reduction in the inflammation of AP 19. In addition, ICAM-1 and vascular cell adhesion protein 1 (VCAM-1) are other two important molecules that involved in leukocyte adhesion [20]. These proteins have been found to mediate leukocyte migration via binding with their ligands on leukocytes such as lymphocyte function associate antigen-1 (LFA-1) (CD11a/ CD18), and macrophage antigen-1 or (Mac-1) (CD11b/CD18) on neutrophils [21,22] as showed in (Figure 1).
During the development of local tissue injury proinflammatory compounds e.g. MIP-2, are synthesised and released. Circulating immune cells encountering such secreted substances are triggered to express adhesion molecules. The leukocyte endothelium interaction reduces leukocyte velocity, enabling rolling and subsequently firm adhesion. These mechanisms are relying on specific subsets of adhesion molecules such as selectins or integrins. Chemotaxis along a concentration gradient directs the inflammatory cells to the site of injury. Having established that activated trypsin has a key role in activation of trypsinogen by proteolytic cleavage and in turn trypsin can rapidly activates other pancreatic proenzymes [23]. In fact, a previous study has found that the initial step of trypsinogen activation is independent on neutrophils, however, later on trypsinogen activation showed to be dependent on neutrophils 9.

Role of Neutrophil Extracellular Traps in AP

A growing line of evidences has shown that neutrophils consider the first defense line against different infectious invaders such as bacteria, fungi and protozoa. During the inflammation, neutrophils chemoattracted and migrate the blood vessels toward the inflamed tissue by following the chemotactic compounds [24,25]. Activated neutrophils can use various mechanisms to kill invading pathogen. For example, neutrophils have been observed to release web-like structures called neutrophil extracellular traps (NETs) [26,27]. Structurally, NETs consist of DNA, histones, neutrophil elastase and myeloperoxidase (MPO) as well as embedded antimicrobial granular proteins [28,29]. NETs are released to extracellular spaces by process called netosis which is another type of cell death program that results in decondensation of neutrophil chromatin [30]. In fact, NETs consider as sword with two edges. On one hand, NETs have shown to provide the host with a defense mechanism against invading pathogens by trap and kill them [28]. On the other hand, it has been shown that NETs have a potent inflammatory role in various inflammatory diseases such as rheumatoid arthritis (RA) [31], vascular disorder [32], inflammatory lung diseases [33]. Moreover, Merza et al have observed for the first-time formation of NETs in the inflamed pancreas [34], as shown in (Figure 2).
1. Scanning electron microscopy showing extracellular web-like structures in the pancreas from a mouse exposed to taurocholate. Scale bar: 5mm.
2. A higher magnification of the indicated area of interest from (Figure 1) showing fibrillar structures compatible with NETs in the inflamed pancreas. Scale bar: 2mm.
3. Transmission electron microscopy of the indicated area of interest from (Figure 1) incubated with gold-labeled antihistone 2B (large gold particles) and anti-elastase (small gold particles) antibodies. Scale bar: 0.25mm [35].
Mechanically, the authors have found that peptide arginine deminase (PAD4) regulates NETs formation and inflammation in AP 35. Moreover, they found also that protein signaling also regulate NET formation in AP. for example, they found that c-abl kinase regulates NETs formation via controlling reactive oxygen species (ROS) generation 13, as showed in (Figure 3). Quantification of ROS formation in isolated neutrophils by flow cytometry. TNF-𝛼 stimulation of neutrophils with or without GZD824. No stimulated neutrophils served as a control. Representative histogram of ROS generation and aggregate data. Data represent mean ± SEM and n = #P<0.05 versus control and *P < 0.05 versus vehicle + TNF-α [35].

To read more about this article....Open access Journal of Anaesthesia & Surgery

Please follow the URL to access more information about this article
https://irispublishers.com/asoaj/fulltext/neutrophil-extracellular-traps-and-acute-pancreatitis.ID.000508.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers

Thursday, March 19, 2020

Iris Publishers- Open access Journal of Neurology & Neuroscience | Lingual Spasms Associated with Internal Carotid Artery Tortuosity




Authored by Mervat Wahba*

Abstract

When a mass is visible in the anterior aspect of the neck of a patient, differential diagnoses of masses as tumors, lymph nodes or vascular lesions are contemplated. When the lesion is pulsating, on the right side of the anterior neck, a tortuous innominate artery simulating a mass is likely. We describe a case of innominate and right carotid artery tortuosity that was detected while treating the patient for a hypertensive urgency.

Case Report

This is a 53-year-old lady presented to the hospital for treatment of hypertensive emergency. Her blood pressure was 220/114 upon arrival. Neurology was consulted for evaluation of episodic tongue spasms with left deviation of the tongue that started an hour before arrival to the hospital. There was no loss or alteration of consciousness, no epileptic activity. There was no chief complaint of weakness, visual or speech abnormalities [1]. A right supraclavicular pulsating mass was noted. There were bilateral carotid bruits. The neurological exam was normal. MRI of the head was negative for acute stroke. Magnetic resonance angiography and computerized CT angiography showed an ectatic right brachiocephalic vessels with tortuosity of the right extracranial internal carotid artery [2] (Figures 1&2).

Hypoglossal nerve vascular supply

The nerve is supplied by arteries that arise from the ascending pharyngeal artery as it exits from the hypoglossal canal, the occipital artery as the nerve passes under its branch to the sternomastoid muscle, direct branches from the external carotid artery, and branches from the ascending pharyngeal artery just near the bifurcation of the common carotid artery [4]. Within and close to the tongue, the nerve is supplied by branches from the lingual artery (Figures 3 to 5).

A possible mechanism explaining the hemi lingual spasm
The hypoglossal nerve leaves the intracranial space by the hypoglossal canal passing into the carotid trigonum through the gap between the internal jugular vein and the ICA. At this level, hypoglossal palsy is most frequently caused by benign and malignant tumors such as schwannoma, chordoma, metastasis, nasopharyngeal carcinoma and lymphoma [5]. Tortuosities of the extracranial ICA may be asymptomatic or mostly present clinically with transient ischemic attacks and extremely rarely with lesions of the caudal cranial nerves.
The tortuosity of the extracranial ICA may have caused stretch of the hypoglossal nerve leading to focal excitation and hyperactivity of the hypoglossal nerve. This mechanism may be similar to that of trigeminal or glossopharyngeal neuralgias. The blood pressure was managed per protocol. The lingual spasms did not recur. Stroke prevention education was offered [6]. The patient continues to be neurologically intact. There was no recurrence of abnormal movements [7,8].

Conclusion


Tortuosity of the innominate and carotid artery is uncommon, is more likely to accompany chronic hypertension that causes loss of elasticity of the vascular wall. Genetic factors contributing to this finding are unclear. Search for other vascular anomalies in the patient by performing vascular studies, secondary stroke prevention is crucial in managing this condition. Caution should be exercised in approaching these patients should emergent tracheostomy is required. Tortuous arteries may not need surgical treatment as long as no focal stenosis or aneurysmal dilatations accompany the condition.


To read more about this article....Open access Journal of Neurology & Neuroscience

Please follow the URL to access more information about this article
https://irispublishers.com/ann/fulltext/lingual-spasms-associated-with-internal-carotid-artery-tortuosity.ID.000550.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers

Tuesday, March 17, 2020

Iris Publishers- Open access Journal of Complementary & Alternative Medicine | We Need Stories and Bibliotherapy Offers One Solution to Developmental Issues



Authored by Pirjo Suvilehto*

Abstract

The power of stories, that is, bibliotherapy and literary arts, lies in the field of literature and in the knowledge of new ways to gain wellbeing and joy through literary practices, specially, in education. In this short paper I discuss about the benefits of developmental bibliotherapy, which means active interaction with a child through a story and its fictional characters. A well-chosen and an appropriate book may be a solution for many daily concerns [1,2].
Keywords:Bibliotherapy; Children and adolescents; Literature, Drama education

Introduction

The objective of this short Opinion writing is a modest demand for scientific renewal of the early phase of my doctoral research [3] and my academic writings after that until 2019. Bibliotherapy in an educational context for children and adolescents is a resource that is not enough well known among teachers. My aim is to produce and distribute knowledge of the ways in which literature and literary arts can be practiced as a means of bibliotherapy, especially in educational contexts. My intention is to develop a cost-effective method of university level education, and to broaden the concept of literature in the mentality of wellbeing e. g. with the method of Pritney TM. Thus, the concept of bibliotherapy and its inherent potential will be transferred into practice on an educational level (universities), in childcare, kindergartens, pre-schools and in schools along with our national project called Hand in Hand.

Discussion

Literature has a positive impact on a child’s development and wellbeing [4,5] and bibliotherapy is an under-used resource in the field of education. The combination of children and bibliotherapy is significant in a world, where literary skills are ever more needed, and I do not mean the importance to gain merely practical reading skills. Bibliotherapy is a therapeutic approach that uses literature (poems, stories, creative writing etc.) to support mental health. Literature may be used for healing and personal growth and be traced back to primitive man in religious rites, where poetry was used for the wellbeing of the tribe or individual. Literature as a healing method dates also back to ancient Greece. In short, bibliotherapy means books and other literature to serve and help (NAPT-The National Association for Poetry Therapy). It means access to benefit from reading skills, but also to experience the joy of reading. It is well documented that stories and literary activities in children’s lives have diverse positive effects and by using carefully selected thematic books teachers can use literature to reach out to students experiencing difficult situations (6,2).
Many teachers in day care and at school practice bibliotherapy in some manner, often without giving their practice a formal name. However, effective follow-up activities, thoughtful questions, and focused discussions require that teachers are mindful about their use of books to address individual and group issues [7]. Teachers are attempting to help students with socio-emotional difficulties, and school professionals are searching for ways to promote skills and adjustment (8). Collaboration between psychologists and educators may be beneficial with bibliotherapy as a tool. There are methods related to bibliotherapy which are available. These methods enable discussions and provide guidelines for practice [9,10]. There are web-pages encouraging families to have ‘important bookreading sessions’ in children’s everyday lives [11,12]. However, systematic in-depth studies on how books may be beneficial as bibliotherapeutic means in challenging situations in educational contexts in kindergartens, schools, or at university are still missing. Although, there are studies on practices in classrooms concerning developmental bibliotherapy (13), the current knowledge is often based mostly on reading skills, while babies’ books and reading habits have been particularly ignored [14,15].
There have also been concerns regarding children’s diminishing reading skills [10]. Additionally, there has been a concern about the growing emotional problems in families and with children in schools, and teachers are finding bibliotherapeutic activities to enhance their wellbeing [16]. Some examples of this include a 10-step process for implementing bibliotherapy in the classroom and providing samples of juvenile books used in bibliotherapy. Responding to these issues, changes need to take place in ways that support meaningful child–reading relations, and sensitive child adult relations. For this to be possible there is an urgent need to know
• What kinds of books and reading sessions are significant to children, but also
• How it is possible to implement bibliotherapeutic reading sessions and interaction with children as part of their everyday lives.
Studies on bibliotherapy, especially academic research into children’s bibliotherapy, and the beneficial use of books in early childhood settings in shared everyday lives are, however, are extremely rare, not only nationally but also internationally.
The disciplinary backbone of my scientific and academic work comprises educational science, literary studies, cultural anthropology and the multidisciplinary fields of posthuman studies and animal studies, childhood studies and psychology. All of the mentioned disciplines are areas in which children’s literature may be used as a vehicle for development and may even involve healing practices and meanings. In particular, affective bibliotherapy even seems to be superior to cognitive bibliotherapy [4] for children, and thus emphasizes the importance of the emotions, effectiveness and sensitivity of adults during reading sessions [17]. The societal significance of the research is anchored in serious consideration of children’s and adolescents’ bibliotherapy and how we may benefit from it on many levels in our society. There is an urgent need for valuable academic research to raise a wider consciousness of bibliotherapy. The research is also valuable for its practical goals in implementing good practices and recommendations to be shared between child health care centers, kindergartens, pre-schools, and schools. A focus on bibliotherapy as “healing words” is an acknowledgement of children as capable, complete, equal citizens and also productive members of society. Children are people who have their own thoughts, imagination, understanding and creativity. Educators, teachers and parents need new vehicles to cope with challenges of wellbeing with children and families in our changing societies. Children have their rights to a good life and to many good daily practices, e.g. at home and, at school and in day care. Making reading a daily, enjoyable routine may be one thing to enhance children’s wellbeing by listening to, what a child is interested in, and to understand, what developmental tasks she/he is going through at the moment [18]. Finnish curriculum of early childhood education and care [18] is based on an integrated approach to care, education and teaching (the Edu care model), and learning through play is seen as essential.
Finland is a unique and timely context in which to study children’s bibliotherapy, as our country is well known from its good educational practices and children’s reading skills. We have a long history with a school library system, and it is well known that Finnish people like to read [19]. So, the assumption is, that reading is part of everyday practices in various areas. The question is, how to maintain the attraction and enchantment of creative reading, and to ensure that educators have good knowledge of the many possibilities brought forward by books and literature which are central in bibliotherapy. Stories may be powerful tools to maintain and enhance wellbeing on an individual and societal level [20]. The relatively independent habit of reading among children in general, in both urban and in rural everyday environments, is internationally renowned [21]. However, there is an increasing concern for children who face serious challenges in their everyday lives, and who have no emotional access to stories, or enjoyable reading moments, and there is a need to encourage families to create reading moments. Additionally, in kindergartens, pre-schools and schools, encouragement is needed to develop good reading skills. Furthermore, as with the idea of bibliotherapy, especially among children and adolescents, preventative, developmental, and interactive bibliotherapy have special tools for adults to maintain wellbeing and enhance joy among children, who have many developmental tasks to conquer.

Conclusion

Previous research on bibliotherapy and children’s relations with books: To summarize, the findings of my previous research (1- 3,14,15,22-25) indicate that/p>
• Bibliotherapy has applications in many contexts, also in children’s lives,
• There is international concern regarding diminishing reading skills of children, and that
• Children’s and adolescents’ (developmental) bibliotherapy are not enough well known among parents, teachers, and educators as a vehicle to create and sustain reading sessions and reading habits, which are significant in children’s’ daily lives.
Without knowledge of children’s views, child-book relations often end up being ignored, or valued or only for their utility towards children’s future development rather than their everyday well-being. Of the research conducted related to children’s reading skills, until recently virtually the entire focus was on children’s development from an adult point of view. Studies seem to locate in the field of education and assess the usefulness of reading skills towards children’s development. Of these studies, a further majority focus on scaffolding, or the use of new media in improving children’s educational skills. Caring, companionship, security, comfort, amusement and joy are items which are essential to developmental and preventive bibliotherapy, and these are the major focus of this Opinion writing. Studies into disciplinary frameworks of children’ s bibliotherapy on an educational level are drastically fewer in numbers and arise mostly from the fields of social sciences, medical science and psychology [26]. The benefits of “power stories” in the everyday life of “healthy” children to enhance their wellbeing in situational and developmental tasks need to be studied.
Studies on child-book relations, within educational sciences in particular, can explore the usefulness of picture books especially in pre-primary education and children’s literature in formal education. Questions which have profound implications for society are virtually unexplored, e.g how student kindergarten teachers can and practicing teachers handle the ever-increasing developmental tasks in the growing multi-cultural contexts of children, e.g. in children’s everyday places such as day care and schools.
At the moment I am working in a national project called Hand in Hand, funded by Finnish Ministry of Education and creating my Pritney Method, which brings forth a concept from bibliotherapy [27], approaching child-book relations from the viewpoints of children in their daily lives, and how books and literary art focused activities have the power to enhance children’s knowledge of themselves, to bring joy and build trust in the future. As in educational settings, this concept is referred to as developmental bibliotherapy and may be used by teachers, librarians and parents, and is meant to help children grow and develop [28-31]. In particular, this project has a special interest also in infants, and how literary arts may be practiced with infants, as well as how parents may be sensitive with their babies and create interaction with rhymes, first books and joyful moments in stories. Especially, pictures that are aimed at infants and their families are lacking evidence in academic research [32,33]. Theoretical-methodological approaches situated in literature studies, childhood studies, in addition to emerging approaches under ‘post humanism’ and psychoanalysis, such as the work of scholars including Freud, Winnicott, Mazza and Pennebaker contest the notion of literature and its benefits in multiple cultural contexts.

Results

Learnt 9 articles found that aloe vera functional to speed up the healing process of wounds into reduce the intensity of pain in the treatment of oral lichen planus, stomatitis, diabetes mellitus, pressure ulcers, venous ulcers, chronic anal fissure, heal burns, burning mouth sydrome, alpthous minor, operation post [8]. So that could be said that the content of aloe vera has function to speed up the healing process of wounds and could reduce the intensity of pain which is due to several health body problems. There is one articles that has different to the efficacy of aloe vera, other to speed up the healing process of wounds and reduce the intensity of pain which one aloe vera gel was encapsulated in liposome was used in the healing melasma process. Because the content aloe vera gel has function as a skin pigmentation modifying agent [9]. Literature learn identified from 9 papers that have been done with critical steps so that from 9 articles discussing aloe vera which are managed or extracted in various forms and has different properties. Application in several treatment related to health problems in the forms of gel cream, juice, and solution of follows.
Aloe vera gel
Four researching articles identified the efficacy of aloe vera gel nonetheless there are differences in other of research. Ghafarzadeh M & Eatemadi A [9] using aloe vera gel extract (AGE) 0,5 % and encapsulated liposomes 1% weight of treatment given to melasma patient with significant results. Shahzad MN & Ahmed N [10] researching using aloe vera (Aloe Tone Je IR) get which is not purified and has 98% gels used for the treatment of superficial burns and partial with the result that aloe vera get can speed up the healing process of wounds and reduce the intensity of pain. López jornet P et al. [11] identify aloe vera barbadensis gel combined and tongue protector it was found that using of aloe vera gel and tongue protector can reduce duration of wound healing to burning mouth syndrome patients. Others researching’s that reduce pain score and wound size but also accelerates the healing of alpthous stomatitis wound [12].
Aloe vera cream
Three researching articles identified aloe vera which is managed into the form of cream. Researching by Babaee N et al. [12] was found using cream of aloe vera oil (AVO cream) toward wounds recovery with results with significant improvement results using pain assessment tools (VAS), AVO cream efficacy statistical test scores increased significantly (p<0.001). Rahmani N et al. [13] identified the effect of aloe vera cream 0,5% in chronic anal fissure treatment and it was found that using aloe vera cream could reduce pain and accelerate the process of wound healing during chronic anal fissure treatment. Eshghi F et al. [14] also identified the using of aloe vera cream into reduce pain and accelerate the process of post-surgery wound healing, post defection (hemorrhoidectomy) and found that aloe vera cream significantly reduced post-surgery pain at 12, 24, 48 hours and 2 weeks post-surgery and patients who is receiving aloe vera cream has decreased when take number two significantly at 24 and 48 hours after hemorrhoidectomy and aloe vera cream significantly helps wound healing to post-surgery patient during 2 weeks.
Aloe vera juice and gel
One researching has been done by Pol JS et al. [8] identified combination of aloe vera juice and gel in oral symptomatic lichen planus treatment, the said by combining treatment juice and gel in symptomatic oral lichen planus treatment reduce the duration of pain.
Aloe vera solution
Mansouri P et al. [15] using aloe vera solution to stomatitis and pain intensity in patient who undergoing chemotherapy procedures and the results were obtained that using of aloe vera solution to reduce the pain of chemotherapy to stomatitis patients are very effective with statistical test results on third day (on the 3rd day) - 14th day P : 0.001 (stomatitis intensity) and P: 0.001 (pain intensity).

To read more about this article....Open access Journal of Complementary & Alternative Medicine

Please follow the URL to access more information about this article
https://irispublishers.com/ojcam/fulltext/we-need-stories-and-bibliotherapy-offers-one-solution-to-developmental-issues.ID.000523.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers

Iris Publishers- Open access Journal of Complementary & Alternative Medicine| Efficacy Aloe Vera in Treatment: A Literature Review



Authored by Moh Rozani*

Abstract

Introduction: Aloe vera is a medical which has many benefits that is used in medicine to several problems in the health of human body.
Aim: Conducting a literature review study related to efficacy of aloe vera which is used for treatment in healing with body health problems.
Methods: Article searching start on date 10 – 25 August 2018 via the CINAHL database, ResearchGate, Pubmed, and ScienceDirect which is used keyword effect AND aloe vera then, selection based on inclusion criteria in the article and after getting results inclusion criteria is done critical appraisal so that relevant articles number of 9 articles.
Results: Of the 9 articles, there were 8 researching articles indicate that using aloe vera has benefits in accelerating the process of wound healing and decrease pain intensity heal burns. There is one researching article indicate date aloe vera can also be used as therapy or treatment in melasma patients with fix function skin pigment. Conclusion: Utilization of treatment using aloe vera proven to accelerate the process of wound healing and decrease some health problems of pain intensity.
Keywords:Leaf aloe vera; Efficacy; Treatment

Introduction

Medical plants are the best source for getting treatment from various disease [1]. Using of natural substances with therapeutic properties has been used since ancient times (Das et al., 2011). At present, several prescribed drugs come from plants [2]. Aloe vera has been used for medical purpose in several cultures for a thousand of years Egypt, India, Mexico, Japan and China [3]. This plant has triangular leaves. Fleshy with jagged edges, yellow tubular flowers and fruits which contain a lot of seeds. Every leaf consults of 3 clear get which of containing 99% water and the other are made of glucomannan, amino acid, lipids, sterols, vitamins, and middle layers of latex which of bitter yellow sap and contains anthraquinone, glycosides, and thick out layer of is 15-20 cells referred to as peel that has a protective function, synthesize carbo hydrates and proteins. Inside the skin is a collection of blood vessels responsible to transport substances such as water (xylem) and starch (phloem) [3]. Various aloe vera extracts are mate to be easy is used in medicine to humans like gel, oil, juice, and tablets. In several researches in-vitro indicate that aloe vera leaves showed contain more than 75 nutrients and 200 active compounds, including 20 minerals, 18 amino acids and 12 vitamins. Also contain the most important components which is needed by the human body Mulu T et al. [4] Aloe vera has vitamins A, B1, B2, B6, B12, C and E. Aloe vera has a high enzyme content (for about 92 enzyme), which makes it a rare source and valuable because of enzyme help the body absorb basic nutrients at the same time purifying it and used as an antifungal, anti-inflammatory, anti-septic, can be used to accelerate the healing process of wounds [5-7]. By looking at kinds of treatment using aloe vera above, so that was done a deep literature to treatment using aloe vera in dealing with health problems.

Aim

Study researching literature that using aloe vera in treatment or therapy to overcome several health body problems.

Methods

Searching article begins of that 10-25 august 2018 by using a search strategy via the CINAHL database, Research gate, Pubmed, and ScienceDirect which is used keyword AND aloe vera and efficacy AND aloe vera and getting number of articles 4822 in all searching database. Then was checked based on the suitability of the title and abstract reading related to treatment using aloe vera and got as many as 1502 articles. Then continued the selection of articles based on inclusion criteria totaling 305 articles which can be seen in the table one. After the article was collected than a critical appraisal in using format Joanna Briggs Institute (JBI) so that of 305 critical appraisal articles the result of all relevant articles was obtained 12 articles.

To read more about this article....Open access Journal of Complementary & Alternative Medicine

Please follow the URL to access more information about this article
https://irispublishers.com/ojcam/fulltext/efficacy-aloe-vera-in-treatment-a-literature-review.ID.000522.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers


Monday, March 16, 2020

Iris Publishers- Open access Journal of Biostatistics & Biometric Applications | Principal Component Analysis of Factors Affecting Ovulation Interval of Selected Women



Authored by Matthew Chukwuma Michael*

Abstract

The factors affecting ovulation interval, like another biological phenomenon are numerous and interdependent. This paper identified the factors to include Age, Height, Weight, Work Time (Stress), Menstrual Duration, Number of Conceptions, Number of Births and Exposure to Sun. It is the aim of this paper to formulate a smaller number of independent random variables such that minimum information is lost. A total of two hundred (200) women in their reproductive age interval were selected for the study. Questionnaires were used to get the relevant information from them. Eighty eight percent (88%) of the total variation in the ovulation interval was accounted for by six (6) principal components compared to the original eight random variables. It was observed that the most important factors are Stress, Height, Menstrual Duration, Weight and Age, and that only Exposure to Sun did not show any significance in affecting Ovulation Interval.
Keywords:Principal Component; Ovulation; Conception; Factors and multivariate

Introduction

The time between two menstrual flows in which egg is released from the ovary into the fallopian tube in readiness for fertilization is called ovulation [1]. Being able to determine the period of ovulation is one of the major challenges to conception and unwanted/unexpected conception. The general believe is that ovulation occurs halfway into the normal menstrual cycle. There are signs and symptoms of ovulation which can help to notice the occurrence of ovulation [2]. The most important sign according to [2] is virginal mucous. Other signs like dizziness, increased body temperature and feverishness exist. Predicting ovulation; that is, knowing when it will occur and when it has occurred is very important for conception [3]. In human population the average duration of ovulation occurrence is 28 days. However, most women experience deviations from this universal parameter. Ultimately, many women experience variation in the interval of their ovulation.
Like every other biological phenomenon, ovulation is affected by some factors which are also interdependent. To enhance a good prediction of ovulation, this work was designed to perform a principal component analysis of some suspected factors affecting ovulation interval in selected women in order to determine a fewer and independent set of random variables.

Methodology

A total of 200 women in their reproductive age were selected for the study. The women were mostly teachers in primary and secondary schools, health workers in public and private health facilities and literate women in market places. The data collection process took place in a period of six weeks. Questionnaires were administered to the women and they supplied the necessary information under proper supervision. The major factors considered for analysis are Age, Height, Weight, Work Time (Stress), Menstrual Duration, Number of Conceptions, Number of Births and Exposure to Sun.
The method of data analysis is Principal Component Analysis. It is a multivariate Technique used in data reduction and data analysis [4,5]. The aim of principal component analysis is to ascertain if the joint variation in p variables can be represented approximately in terms of the joint variation of a fewer number, say k < p , of hypothetical variables without much loss of information. That is X p×1 are replaced by a linear transformation,
irispublishers-openaccess-biostatistics-biometric-applications
Where Yp×1 k < p are significant and approximately chosen from Yp×1. The Yp×1 are interpretable in terms of the original problem and they are independent [5,6].
irispublishers-openaccess-biostatistics-biometric-applications
The are Principal Components (PC) if they are uncorrelated and their variances are as large as possible.
irispublishers-openaccess-biostatistics-biometric-applications
If the mean vector and covariance matrix of are given as and respectively and, has eigen value – eigen vector pairs; the ith
Principal Component Analysis is given by
irispublishers-openaccess-biostatistics-biometric-applications
with
irispublishers-openaccess-biostatistics-biometric-applications
The total variance is given as
irispublishers-openaccess-biostatistics-biometric-applications
Thus, the proportional variance explained by the kth principal component is
irispublishers-openaccess-biostatistics-biometric-applications
If 80% to 90% of the total population variance for large can be attributed to the first one, two or three components, these components can be used to replace the original variables without much loss of information.
When the variables, are in different units, two or more variables are measured on vastly different ranges or standardized random variables are used instead of the original random variables, the correlation matrix, , is used to calculate Principal Components (PC) instead of Σ [4].

To read more about this article... Open access Journal of Biostatistics & Biometric Applications

Please follow the URL to access more information about this article
https://irispublishers.com/abba/fulltext/principal-component-analysis-of-factors-affecting-ovulation-interval-of-selected-women.ID.000521.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers

Iris Publishers- Open access Journal of Biostatistics & Biometric Applications | Biostatistical Analysis on Fagopyrum Tataricum Gaertn



Authored by Bin Zhao*

Abstract

The effects of nitrogen application at different levels (0, 45, 135 and 225 kg/ha in 2015 and 0, 90, 180, 270 kg/ha in 2017) on the physicochemical characteristics of Fagopyrum tataricum Gaertn starch were studied by field experiments. Starch from Fagopyrum tataricum Gaertn with application of nitrogen showed lower amylose content, particle size, and retrogradation, and higher structure complexity, pasting temperature, gelatinization enthalpy, relative crystallinity, light transmittance, solubility of the starch. Nitrogen application did not change the ‘A’-type crystalline pattern of Fagopyrum tataricum Gaertn starch. This study indicated that nitrogen level and years and the interactions among nitrogen fertilizer levels and years significantly affected physicochemical properties of Fagopyrum tataricum Gaertn starch. The integrated results also provide some information into the management of the fertilization conditions to obtain starches with special properties for applications in food or non-food industries.
Keywords:Fagopyrum tataricum gaertn; Nitrogen; Starch properties

Introduction

Fagopyrum tataricum Gaertn (Tartary buckwheat) is an annual dicotyledonous pseudo cereal of the Polygonate family [1]. It can grow under low input conditions and be adapted to marginal lands with harsh environments [2], and it is cultivated mainly in southern China, northern India, Bhutan, and Nepal [4]. Fagopyrum tataricum Gaertn is one of the main minor grain crops and important medicinal crops rich in flavonoids over the world. Fagopyrum tataricum Gaertn has a great efficacy to reduce hypoglycemia hypolipidemic, even can be used to support the prevention and treatment of diabetes, high blood fat, hypertension and other diseases because of inutrient— rich and it’s rich in flavonoid. Nitrogen is an essential nutrient for Fagopyrum tataricum Gaertn due to its effects on the yield and quality of Fagopyrum tataricum Gaertn. Starch physicochemical characteristics represent the important parameters of Fagopyrum tataricum Gaertn quality.
Recently, Fagopyrum tataricum Gaertn is catching more attentions because it contains high nutritional content (e.g., antioxidants, protein, dietary fiber, and resistant starch) and disease-preventative roles [3]. Fagopyrum tataricum Gaertn can be used for the production of many products, such as noodles, breads, cakes, teas and alcoholic drink [6]. The starch is the major component of Fagopyrum tataricum Gaertn seed and its content is high and around 70% [4]. Fagopyrum tataricum Gaertn starch had special physicochemical properties and is thereby capable of being exploited as a potential source of retrograded starch [5]. And it is also responsible for the textural properties of Fagopyrum tataricum Gaertn products in the absence of gluten protein [6]. Compared with wheat and corn starch, Fagopyrum tataricum Gaertn starch has a higher amylose content (20%-28%), a better water-binding capacity, more stable pasting properties, and lower percentage of retrogradation [7]. Fagopyrum tataricum Gaertn starch consists of amylopectin and amylose. The amylose content is one of most important traits to impact the quality of Fagopyrum tataricum Gaertn.
The structure and physicochemical properties of Fagopyrum tataricum Gaertn starch are affected by genetic background, soil conditions, climatic conditions and agricultural treatments during Fagopyrum tataricum Gaertn growth and development [8]. Nitrogen is an important and non-negligible environmental factor affecting crop quality. Many studies suggested that nitrogen fertilizer is not contributing to crop quality improvement, but many research results showed that appropriate nitrogen can maintain and improve crop quality [9,10]. Previous studies suggested that nitrogen fertilizer can significantly lower the peak viscosity, hot paste viscosity, cool paste viscosity, breakdown viscosity, amylose content and improve the physicochemical properties of rice starch [11,12], and affect the biosynthesis and quality of barley starch [13]. However, the effects of nitrogen fertilizer on starch were mainly studied on maize [14], wheat [15] and barley [13], rice [16]. To the best of our knowledge, there are few reports on how nitrogen application affects the physicochemical properties of Fagopyrum tataricum Gaertn starch. Therefore, it is essential to compare the physicochemical characteristics of Fagopyrum tataricum Gaertn starch of varied levels of nitrogen application and to evaluate the most optimum amount of nitrogen fertilizer applied to achieve high quality for its potential use in the food and non-food industries.

Material and Methods

Plant materials and experimental design
Seeds of the variety No. 2019 of Fagopyrum tataricum Gaertn were collected in the test farm (109.7E, 38.3N, altitude 1080 m), Yulin, Shaanxi Province, China. The soil type is sandy loam. The crop previous to Fagopyrum tataricum Gaertn was nursery. Soil had 0.15% total nitrogen, 1.82 mg/kg available phosphorus, and 21.65mg/kg available potassium. These seed samples were grown under the same conditions. The meteorological data was offered by agricultural meteorological information service platform.
The experiment was arranged in a randomized block design. The nitrogen level included 0, 45, 135 and 225 kg/ha in 2015 and 0, 90, 180, 270 kg/ha in 2017 (non, low, medium and high nitrogen level). All the groups were treated with potassium (K) 37.5 kg/ha and phosphorus (P) 37.5 kg/ha. Seeds were sown on July 10 and the harvest time was October 7. Nitrogen fertilizer was applied in the form of base fertilizer and then no longer topdressing during the growth of Fagopyrum tataricum Gaertn. Other practices were in conformity with local recommendations.
Starch isolation
Five hundred grams of the Fagopyrum tataricum Gaertn seeds of the different treatments were separately taken, ground with universal high speed smashing machines (FW100, Taisite LTD, Tianjin, China) and sieved with 200 mesh (< 75 μm) sieve to obtain Fagopyrum tataricum Gaertn flour. Fagopyrum tataricum Gaertn flour with 80% ethanol with the solid-liquid ratio of 1:20 was treated at 50 °C for 30 min by ultrasonic treatment at the power of 500 W to remove the flavonoids. Then add distilled water at the solid-liquid ratio of 1:10 (g/mL), and soak in a water bath at 30 °C for 18 h to remove protein. Let it stand for a few minutes and then pour off the upper suspension and place it in an oven at 40 °C. After removing the fat with petroleum ether, the excess petroleum ether was washed away with 80% ethanol and washed repeatedly with water. Centrifuged at 4000 r/min for 10 min and the supernatant was removed. The upper gray matter was scraped until only white material and the lower white material was poured in a Petri dish or beaker. Finally, the Fagopyrum tataricum Gaertn starch was dried in an oven at 40 °C for 24 h and sieved with 100 mesh (< 150 μm) sieve. The starch was sealed in self-sealing plastic bags and stored at 4 °C for use.
Amylose content
The amylose contents of the starches were measured and calculated according to the method of Yang and Zhang et al. [17]. The absorbance of the solutions of Fagopyrum tataricum Gaertn starches at different nitrogen levels was measured at 434 and 604 nm using the Blue Star B spectrophotometer (Saith Chemical Co., Ltd, Wuhan, China).
Scanning electron microscopy (SEM) observation
The starch samples were affixed to the loading platform of the surface processor using a double-sided adhesive tape, and then put into the processor. The surface morphology of starch granules was observed and then photographed using scanning electron microscopy (JSM-6360LV, Jeol, Japan). The magnification was 2000×.
Granule size analysis
The granule size was carried out using a laser diffraction particle size analyzer (Mastersizer 2000E, Malvern, England). The starch was in tap water and stirred. The instrument could measure starch samples between 0.1 and 1000 μm.
Bivariate flow cytometric analysis
Starch granules were stained according to the method of Zhang, Feng et al. [18]. A bio fluorescent microscope (Imager M2, Carl Zeiss, Germany) was utilized to examine the starch staining efficiency. However, the starch suspension reagent was ddH2O. The Fagopyrum tataricum Gaertn starch granule suspensions were measured using BD FACSAria™ III, BD, America and analyzed using BD Bioscience [18].
Pasting properties
Pasting properties of starch samples were determined using the Rapid Viscosity Analyzer (RVA4500, Parten, Stockholm, Sweden). Three grams of each sample with 14.0% moisture were directly weighed into aluminum RVA canisters, after which, 25.0 mL distilled water was added to achieve a total weight of 28.0 g. The parameters were set: The slurry was held at 50 °C for 1 min, then heated from 50 °C to 95 °C for 3.7 min, and held at 95 °C for 2.5 min. Finally, the sample was allowed to cool to 50 °C for 3.8 min and held at 50 °C for 2 min [19].
Thermal properties
The thermal characteristics of the test starches were determined by a differential scanning calorimeter (DSC) (DSC2000, TA instrument, United States). The DSC analyzer was calibrated using indium. A total of 3.0 mg of the dried starch sample was mixed with two times volume of water sealed in an aluminum pan at room temperature in 2 hours. The sample pans were heated to 110 °C at a rate of 10 °C/min, while one empty aluminum pan was used as the control. The starch gelatinization parameters that the DSC curve involved were onset temperature (To), completion temperature (Tc), peak temperature (Tp) and phase transition enthalpy ΔH [20].
X-ray diffraction analysis
XRD patterns of samples were obtained on an X-ray diffractometer (D8 ADVANCE A25; Bruker, Germany). The starch samples were scanned at 4°-60° (2θ) and a rate of 8 °/min at a target voltage of 40 kV and a current of 40 mA [5]. Relative crystallinity (%) was calculated by using software (MDI Jade 6).
Retrogradation
One percent starch pastes of the samples were prepared and placed into 20 mL graduated test tubes with stopper, 20 mL per tube, and stored at 25 °C for 24 h. During this storage period, the supernatant volumes of the tubes were counted every hour. Accordingly, the retrogradation curve of the supernatant volume percentages with time was drawn [21].
Light transmittance
The light transmittance was measured according to Chao et al. [21] with the Blue Star B spectrophotometer (Lab tech Ltd, Beijing, China) using distill water as their control.
Solubility
The solubility of the starch samples was determined by using the method described by Chao et al. and Liu et al. [22,23]. Each 200 mg starch sample was transferred to a dry centrifugal tube, weighed, and mixed with 10 mL distilled water. Each tube was incubated in a shaking water bath at 60, 70, 80, and 90 °C for 30 min, cooled to room temperature, and centrifuged at 2000 r/min for 20 min. The supernatant was carefully decanted, and the tube with the remaining contents was weighed. The residue obtained after drying the supernatant represents the amount of starch dissolved in water. The solubility of the samples was calculated on a dry-weight basis (DB) through the following equation:
Solubility = the weight of dried supernatant weight of starch
Data processing
All the tests and measurements were repeated trice and the data thus obtained were statistically analyzed by SPSS 19.0 (SPSS Inc., Chicago, IL, USA). All data represent the mean ± standard deviation. Difference significances among the means were tested by the analysis of variance and the least significant difference (LSD) at p < 0.05.

Results and Discussion

The temperature variation of fagopyrum tataricum Gaertn during grain-filling stage
Grain-filling stage is the key period of dry matter and starch accumulation and the temperature is an important parameter that affects the crop growth and development [24]. Fagopyrum tataricum Gaertn began to produce more grains at about 40 days after seeding emergence and there were an end of filling stage at around 80 days for most of the Fagopyrum tataricum Gaertn grains [25]. Therefore, the date from 40 to 80 days after emergence was selected in order to investigate the effect of temperature change on amylose accumulation and starch characteristics. Compared with the maximum temperature in 2017 from 40 to 57 days, the higher maximum temperature and minimum temperature in 2015 could be seen in in the Figure 1A and the similar trend can also be observed at mean temperature (Figure 1C). As shown in the Figure.
1B, there were a lower temperature difference from 40 to 50 days and a higher temperature difference from 50 to 80 days in 2017. Zhang et al. reported that the content of starch and amylose and the activities of key enzymes involved in starch synthetic metabolism in developing rice grains were influenced by different temperatures during grain filling stage [26]. And some studies indicated that heat stress during grain filling generally decreases starch contents and enlarges starch granules [27]. High temperature during early grain development play a more important role in affecting the starch pasting properties, crystalline structure, and granule size of cereal starches than that during late grain development [28].

To read more about this article...Open access Journal of Biostatistics & Biometric Applications

Please follow the URL to access more information about this article
https://irispublishers.com/abba/fulltext/biostatistical-analysis-on-fagopyrum-tataricum-gaertn.ID.000522.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers

Friday, March 13, 2020

Iris Publishers- Open access Journal of Cardiovascular Research | Do Intracoronary Techniques Add Diagnostic Value Beyond Angiography in the Characterization of Myocardial Bridges?

https://irispublishers.com/ojcr/images/irispublishers-openaccess-cardiovascular-research.ID.000536.G001.png



Authored by Pablo Ramos-Ruiz*

Case Report

Myocardial bridging (MB) is defined as myocardial tissue surrounding a segment of an epicardial coronary artery that goes intramurally, mostly involving the left anterior descending artery (LAD). Although patients with MB are often asymptomatic, this anomaly has been related to a wide spectrum of symptoms [1]. Pathogenic mechanisms leading to ischemia in MBs are not completely ascertained [2]. In this regard, angiography alone is often inadequate to fully appraise morphology and funcional repercussion of a MB. Recently, the instantaneous wave-free ratio (iFR), a resting trans- stenotic pressure gradient measured at the diastolic “wavefree” period, has been proposed as a promising tool in assessing the hemodynamic relevance of MBs [1,3]. A 59-year-old male with hypertension and dyslipidemia was referred to our department due to stable effort angina and a stress echocardiography showing reversible ischemia in the LAD myocardial territory. The coronary angiography Figure 1, Panel A showed a tunneled segment of the mid LAD with systolic compression, “milking effect” (white arrows). Given the clinical presentation, a comprehensive imaging and functional intracoronary study was performed in order to better characterize the LAD-MB. The intravascular ultrasound (IVUS) study Figure 1, Panel B demostraste a systolic concentric compression of the bridged segment, that persists into diastole with the typical finding of the “half- moon phenomenon”, an echolucent area present between the bridged coronary segment and epicardial tissue (white asterisk) [1]. The cross-sectional lumen area variation was 22%. Of note, IVUS ruled-out significant atherosclerotic burden, coronary dissection and other complications associated with MB. The functional assessment of the mid LAD-MB revealed a significant resting diastolic pressure gradient, as measured by iFR (iFR 0.84, Figure 1, Panel C) with the sensor of the pressure-wire located distal to MB segment (whit arrows, Figure 1, Panel D). Given the demonstrated functional repercussion of the MB, concordante with the results of the stress echocardiogram and the patient symptoms, it was decided to optimize the medical treatment aimed to the control of angina. However, three months later, our patient persists symptomatic. Here, in summary, we present a case in which imaging and intracoronary physiology techniques were useful for a better morphological and functional assessment of a MB.




To read more about this article... Open access Journal of Cardiovascular Research

Please follow the URL to access more information about this article
https://irispublishers.com/ojcr/fulltext/do-intracoronary-techniques-add-diagnostic-value-beyond-angiography.ID.000536.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers

Iris Publishers- Open access Journal of Cardiovascular Research | Primary Cardiac Lymphoma Case Report

https://irispublishers.com/ojcr/images/irispublishers-openaccess-cardiovascular-research.ID.000535.G001.png



Authored by Rios Dueñas Giovanny*


Abstract

Primary heart tumors are very rare. Reyne et al. reported a prevalence of 0.02% for heart tumors in 22 autopsies [1]. Primary heart lymphomas are even more rare, with a prevalence between heart tumors from 1 to 2% and 0.5% of all lymphomas [1,2]. We will report one case of a 69-year-old woman with a mass in the right atrium, with hemodynamic compromise, with the histological finding of a primary heart diffuse type B lymphoma.
Keywords:Heart lymphoma; Heart tumors; Diffuse type B Lymphoma; Cardiac lymphoma; diffuse large B-cell lymphoma; Cardiac tumors

Summary

Primary tumors of the heart are quite rare. In a series of 22 autopsies conducted by Reynen et al. [1] found a prevalence for cardiac tumors of 0.02%. Primary cardiac lymphoma is even rarer, with a prevalence between cardiac tumors of 1% to 2% and 0.5% of all lymphomas [1,2]. The case of a 69-year-old woman with a diagnosis of intracardiac mass will be reported, which in the histological studies of this mass evidenced compromise by primary cardiac lymphoma.

Case Report

This is a 69-year-old patient who consulted the emergency department of San Ignacio Hospital for presenting a clinical picture of functional class deterioration, progressive dyspnea at medium and low effort, associated with a palpitation sensation. In the interrogation without significant background. It is evaluated by the emergency department, which, in view of the characteristics of the clinical picture and the presence of indirect signs of heart failure, requests computerized axial tomography with a pulmonary artery protocol to rule out pulmonary embolism and thromboembolism. This study reports a moderate pericardial effusion associated with the presence of a mass that occupies 90% of the right atrium with extension to the superior and inferior vena cava. Given these findings, an assessment was requested by the cardiology service, who performed a dynamic study with a trans-esophageal echocardiogram in which the mass with soft tissue echodensity, 7.5 x 55mm, with compromise of the arrival of the superior cava, was demonstrated. Endoluminal compromise of 50 to 95% in the atriocaval junction. In addition to pericardial effusion in moderate amount without echocardiographic signs of cardiac tamponade. With these findings, it is taken to the surgical medical board in which the cardiovascular surgery service considers a candidate for surgical intervention for extraction of atrial mass and pathological study of it. Medium sternotomy is performed; Dissection of fibrotic pericardium and opening thereof, pericardial effusion is identified in the images of bloody characteristics. Cardiopulmonary bypass is established; arterial cannulation of the aortic root, venous cannulation by superior vena cava and by right femoral vein due to the tumor invasion presented in the inferior vena cava. Right atrial opening, without aortic clamping. Dissection of right atrium mass is started without complete extraction, given the presence of infiltration to the posterior wall of the right atrium, superior cava, inferior cava, interatrial septum and tricuspid valve. Given the unresectability is considered auriculorrhaphy with cardiovascular prolene 4.0 in 2 planes.
Removal of aortic clamp and cardiopulmonary bypass output without complications. Aortic clamp and cardiopulmonary bypass times, 17 min and 32 min respectively. The patient is transferred to the intensive care unit for surveillance. In the results of the histological studies, diffuse large B-cell lymphoma, primary of the heart, positive for CD45, CD20 and Bcl16, cellular proliferation index (Ki67) of 70% was identified. Negative for Bcl2, abundant CD68 positive histiocytes and CD3 positive T lymphocytes.
The pathology shows Diffuse B-cell lymphoma activated phenotype.
• Tumor cells of high grade of malignancy positive for CD20, Bcl6 and MUM-1 with a cell proliferation index (Ki67) of 70%. They are negative for Bcl2 and CD10.
• IAE Stadium
• Cardiac Commitment (POP resection of cardiac tumor (07/31/2017).
• High-intermediate risk (IPI 3).
Echocardiography:(07/24/17) Moderate eccentric hypertrophy, LVEF 60%, AD dilated.
It goes through its postoperative period without complications. The cardiac block is reversed, and it is discharged. Later in controls the patient presented after the second click of chemotherapy, heart block. A definitive transvalent unicameral pacemaker was implanted, which is functional. The patient has been followed for 2 years. She received for treatment 6 cycles of chemotherapy, R-CHOP21 protocol x 6 cycles. Lead a life with acceptable quality. It is independent in its functions. It is in the process of recovering secondary alterations to chemotherapy Figure 1.



To read more about this article... Open access Journal of Cardiovascular Research

Please follow the URL to access more information about this article
https://irispublishers.com/ojcr/fulltext/primary-cardiac-lymphoma-case-report.ID.000535.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers

Thursday, March 12, 2020

Iris Publishers- Open access Journal of Agriculture and Soil Science | On Accounting for Evaporation or Infiltration Free Surface in Some Problems of Filtration Theory

https://irispublishers.com/wjass/images/irispublishers-openaccess-agriculture-soil-science.ID.000544.G001a.png


Authored by Bereslavskii Eduard Naumovich*

Introduction

Within the theory of the flat established filtering of an incompressible fluid under Darci’s law in homogeneous and isotropic soil some tasks connected with currents in the presence of evaporation or infiltration on a free surface of subsoil waters are considered.

Currents at Flow of a Groove Zhukovsky

The task about flow of a groove was for the first time studied by N.E. Zhukovsky [1] where Kirchhoff’s method altered by it in the theory of streams was used for a solution of tasks with a free surface and special analytic function which is widely used in the theory of filtering is entered. Since function, and a task and a groove bear a name of Zhukovsky [2–6]. Work [1] opened a possibility of mathematical modeling of the movement of subsoil waters under Zhukovsky’s groove and laid the foundation for researches of the specified class of filtration currents (see, for example, reviews [2- 6]).
It should be noted that in tasks about flow of a groove of Zhukovsky application of function of Zhukovsky only then results in effective results when in addition to a free surface the border of area of a current contains only horizontal lines of equal potential and vertical lines of current (V.V. Vedernikov, F.B. Nelson Furriers, S.N. Numerov, V.I. Aravin, etc.). However in actual practice hydrotechnical construction [2-5], the irrigated agriculture [2,4,7], etc. directly under integumentary deposits along with horizontal pressure head water-bearing layers more high-permeability [7] also horizontal waterproof inclusions often meet that radically affects the nature of filtration currents [8–12].
At the same time so far, there are no works devoted to a special research of impact of evaporation or infiltration on filtration processes. Accounting of these important physical factors for the present did not become broad property of exact analytical solutions.
In the presented work on the example of two limit filtration schemes which arise at flow of a groove of Zhukovsky, the impact of evaporation or infiltration on a current picture is studied.
The first limit scheme corresponds to a case when the layer of earth on all the extent is spread by the impenetrable horizontal basis and from a free surface there is a uniform evaporation of intensity ε (0 <ε <1). The current is provided with water inflow from the left part of a band of flooding with a liquid layer, invariable on time. As the right edge of a band of flooding serves the impenetrable vertical screen in the form of a groove of Zhukovsky which basis is located in layer, at the same time the static height of a capillary raising of a subsoil water can be considered (Figure 1(a)).

In the second limit scheme the layer of earth is spread by well permeable pressure head aquifer in which pressure has constant H0 value, and on a free surface there is a uniform infiltration of intensity ε [13-16]. Far from a groove (at x →∞) the curve of a depression is horizontal and located at H0 height over an aquifer (Figure 1(b)).

Currents in A Rectangular Jumper with Partially Impenetrable Vertical Wall and To Imperfect Gallery

The exact solution of a task on a fluid influx to the imperfect well with the flooded filter (i.e. an axisymmetric task) or the tubular well representing an impenetrable pipe with the filter in some (usually lower) its part is connected with great mathematical difficulties and so far is not found. Therefore, in due time as first approximation to a solution of similar tasks by P.Ya. Polubarinova- Kochina, V.G. Pryazhinska, V.A. Postnov and V.N. Emikh [2,6,7,17,18] considered some corresponding flat task analogs about filtering in a rectangular jumper with partially impenetrable vertical wall and to imperfect gallery. It should be noted that areas of values of complex speed in the specified cases allow to apply by means of inversion at a solution Christoffel-Schwartz’s formula.
 In work the exact analytical solution of a task on a current of subsoil waters in a rectangular jumper with slopes of A0A1 and D0B, width of L located on the impenetrable horizontal basis of length of L is given. Water height is equal in an upper bye to H, lower reach with water level of H2, having partially impenetrable vertical wall CD (screen), adjoins a basis sole. The upper bound of area of the movement is free pover khnost AD which is coming out with which there is a uniform evaporation to intensity ε (Figure 2). In the considered area of complex speed, unlike [2,6,7,17,18], there are not rectilinear, but circular polygons that does not give the chance to use classical integral of Christoffel-Schwartz.




To read more about this article.... Open access Journal of Agriculture and Soil Science

Please follow the URL to access more information about this article
https://irispublishers.com/wjass/fulltext/on-accounting-for-evaporation-or-infiltration-free-surface-in-some-problems-of-filtration-theory.ID.000544.php

To know more about our Journals....Iris Publishers

To know about Open Access Publishers

Iris Publishers-Open access Journal of Hydrology & Meteorology | Influence of Community Resilience to Flood Risk and Coping Strategies in Bayelsa State, Southern Nigeria

  Authored by  Nwankwoala HO *, Abstract This study is aimed at assessing the influence of community resilience to flood risk and coping str...