Increasing the Probability of Discovering Improved Antiepileptic Drugs through the Use of Human Epileptic Tissue - Pharmacy & Pharmacology Research

 

Epilepsy affects millions of people world-wide with wide-ranging health and economic  consequences [1]. A  first-line approach  to  the  control of epilepsy is through  the  administration of anticonvulsant drugs sometimes referred to as antiepileptics [2]. These medicines help control seizure activity but the evidence for controlling disease progression in patients is not firmly established [3].  There are many antiepileptics approved for clinical use [2] that dampen excitatory   neurotransmission  through   different   mechanisms   including   positive   allosteric   modulation   of GABA (e.g., diazepam, valproic acid)  and blockade of ion channels (e.g., gabapentin, lacosamide).

 

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