Investigation of Leptin Receptor and Enos Gene Polymorphisms in Preeclamptic Umbilical Cords - Gynecology & Womens Health

Preeclampsia is associated with high blood pressure and proteinuria during pregnancy. Preeclampsia causes complications in 2-8% of all pregnancies, premature birth in 15% and maternal death in 9-26% of all pregnancies [1]. In preeclampsia patients, decrease in uteroplacental blood flow rate as a result of vasoconstriction in the umbilical artery may have serious consequences such as intrauterine  growth restriction, preterm birth, fetal death. The etiology of preeclampsia is not clarified yet. However, it is thought that lipid peroxidation due to the activity of reactive oxygen species (ROS) may be the reason.

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