Down’s syndrome and Alzheimer Disease Imaging Genetics

Authored by Ahmed Bashir 

The advancement of both in vivo imaging modalities that detect the neuropathologist associated with both Down’s syndrome and Alzheimer’s disease present new opportunities to explore these diseases in living human subjects. Previously, these neuropathologists could not be detected until after autopsy or in the living patient, with the rarely taken brain biopsy. The use of quantitative traits derived from these imaging modalities offers increased power to detect associations with large scale genetic data, and these studies fall under the category of imaging genetics. Imaging genetics studies can identify novel risk genes and elucidate gene function and novel mechanisms disease pathology and etiology. Recent imaging genetics studies of the neuropathologist of Ad and DS Have attempts to obtain a more complete and in depth understanding the underlying genetic etiology of their pathogeneses. Here we will briefly overview both diseases, the neuropathologist associated with each, the imaging modalities used to detect these pathologies, and finally, the studies combing these imaging modalities with genetic data.

 

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