Authored by Sergio Alberto Ramirez-Garcia*,
Opinion
The TJP1 gene is a very important gene that can be used as a molecular marker of physical performance, as it has been shown to participate in the absorption of nutrients at the level of intestinal villi (glucose, lipids, solutes, among others) both at paracellular level as in the basement membrane of these cells, which is very important at a nutritional level because a good intestinal absorption ensures a better nutritional status, which favors having better macro and micronutrient reserves, which is a determining factor for high performance
However, this is a frontier of research, since there are no studies of sports genetics focused on the analysis of polymorphisms in this gene in relation to physical performance, nutritional status, quality of nutritional intake or factors of body composition. And more if we consider that Type 1 narrow junctions, which are encoded by this gene are very important to maintain the architecture and cell differentiation wich are very important at two levels at the level of adipose tissue and at the level of the precursor cells of the arcuate nucleus. In this case, if they have an adequate structure, on the one hand there is an adequate reserve and oxidation of fats in the adipose tissue, and on the other hand it maintains the architecture of the arcuate nucleus, which allows adequate function of the orexigenic and anorexigenic pathway, regulating satiety as well as hunger. Both factors allow to determine a better physical body composition and utilization of fat from adipose tissue, such as muscle fat [1,2].
Certainly, there are few variants that have been studied of the narrow type 1 Union, but it is a virgin field for geneticists and molecular biologists who are dedicated to the study of body composition. In this sense, genetic marker of the gene that leads to amino acid changes, such as polymorphism rs229166, leads to a conformational change in the ZO-1 structure, which is realetd to the albuminuria [3]. One of those polymorphisms is rs1038306187 leading to the change of amino acid p. Gln791Glu in the domain guanylate kinase. The domain ZU5 has 33 polymorphisms leading to conformational changes. The polymorphisms that affect gene expression by nucleotide changes at the cryptic sites of the alternative splicing are rs781148827, rs5478300017, rs78014403 and rs1020739943 in acceptor region, and rs1029122894 in the donor region, but none of these polymorphisms have been explored for their pathogenic effect. Due to effect on ZO-1 expression, they are a new frontier of research in the also fitness performance [4].
On the other hand, polymorphic markers of this gene could be very useful too in the detection of cardiovascular problems or arrhythmias such as arrhythmogenic dysplasia, which are a very important cause of sudden death in many athletes and highperformance athletes. The association with these conditions can make it possible to detect people at risk before death during routine training or during the performance of sports activity [5].
Undoubtedly, the detection of the markers of the TJP1 gene in athlets can be very useful as a law or a health policy in centers and sports clubs for the prevention of deaths due to cardiovascular problems, or to select sports talents with greater physical abilities and sports.
To read more about this article...Open access Journal of Orthopedics Research
Please follow the URL to access more information about this article
https://irispublishers.com/gjor/fulltext/polymorphisms-in-the-tjp1-gene-like-a-marker.ID.000533.php
To know more about our Journals...Iris Publishers
To know about Open Access Publishers
No comments:
Post a Comment