Wednesday, October 30, 2019

Iris Publishers-Open access journal of Cancer Research & Clinical Imaging | Practical Use of Amino Acids in Oncology: Replacement Therapy as a Structural Components of Proteins and/or for Correction of Metabolism in Quantities Comparative with their Endogenous Concentrations?



Authored by L Nefyodov

The aim of our research is the formulation of methodology creation for practical application of the regulatory action of endogenous (physiological) concentrations of separate amino acids or their pathogenetically justified compositions [1-4]. Changes in amino acid pool in liquids and their tissues fund of oncology patients specifically characterize development of cancer and largely induced by metabolic competition between the tumor and the tumor carrier [5-10]. Correction of the intermediate metabolic changes in cancer can be reached by the use of certain amino acids or their combinations. Based on the positions of metabolomics, the free amino acid pool in biological fluids and tissues is regarded as a single information unit which is a kind of “a chemical projection” of the genome, the proteome realized through this approach not only develops ideas about the pool of amino acids as a dynamical system-generated supply of them from outside, but also due to endogenous synthesis, transport, degradation and excretion and allows the identification of “key points” in intermediate metabolic equilibrium shift that may reflect ratios at the individual levels of endogenous amino acids and related species (metabolicallyrelated) compounds to achieve “metabolic comfort” [11-15].

On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in fluids and tissues are criteria in early diagnostics as in estimation of the efficacy of specific cancer treatment. Our clinical studies on biological fluids and tumors more than 1400 patients with cancer depending on the location and stage of the process showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown [16-18]. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.
None.
No conflict of interest.


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Iris Publishers-Open access journal of Cancer Research & Clinical Imaging | Report the Effective of Integrated Palliative Care using for Advanced Cancer as Second-Line or Later Treatment by Herbal Extractive Medicine



Authored by Pu Rong

Background: The on-going treatments of unresectable pancreatic, hepatocellular and late-stage lung cancer (PC\HCC\LC) are less effectiveness as second-line or later treatment. However, the palliaitve care is alternative option. Here, we reported the patients who received palliative care by herbal extractive medicines (CHM).
Methods: 13 pancreatic, 31 hepatocellular and 168 lung cancer patients were enrolled. CHM (Senghuang, SH; Xianhe Baijiang, XB), which approved by the China Food and Drug Administration (CFDA), hyperthermia and arginine were initiated. Survival time, quality of life (QOL) and toxicity were evaluated.
Result: The average ECOG score improved and no severe hematology and digestion side-effects were observed. In PC group, the median and the average survival time were 5.1 and 6.5 months; The 3-, 6-, and 10-month survival rates were 92.3%, 46.2%, and 30.8%, respectively. The longest survival time was 16.7 months and patient still alive. In HCC group, the average and median survival time were 12.48 and 5.03 months; The 3-, 6-, and 12-month survival time rates were 77.42%, 38.71%, and 29.03%, respectively. The longest survival time was 84.2 months. In LC group, the 6 months, 1-, 2- and 5-year survival time rates were 33.93%, 19.05%, 14.29% and 4.17%, respectively. Meanwhile, in lung cancer group, once the survival time was over 6 months, the average and median survival time were 29.98 and 14.80 months; and the 1-, 2- and 5-year survival time rates were up to 56.14%, 42.11% and 12.28%, respectively.
Conclusion: CHM can be considered as complementary and alternative medicine that provide moderate effective and low toxicity for advanced cancer.

Introduction

Lung cancer (LC), hepatocellular carcinoma (HCC) and pancreatic cancer (PC) are severe malignant cancer. According to GLOBOCAN 2012 report, accounting for 19.45% of all newly diagnosed pancreatic cancer cases in China and 19.27% of all deaths from pancreatic cancer worldwide [1]. Usually, surgery, chemotherapy, radiation therapy and target therapy are used as the first line treatment. Surgery should have been a potentially curative therapy for early stage lung cancer, hepatocellular carcinoma and pancreatic cancer [2], however, many patients are not eligible for surgery [3]. For instant, surgical resection may offer a 5-year survival up to 70% in liver cancer patients, but for patients with advanced disease, surgical resection is an option for less than 20% [4]. Recently, PD-1 and PD-L1 anti-body therapy had been approved in lung and liver cancer, but no standard treatments for such stage patients after 1st/2nd line failure are recommended. Nowadays, the median overall survival (OS) for late-stage liver, lung and pancreatic cancer were 7.9 months, 8.2 and 5.3 months, respectively [1, 5-8]. Integrated palliative care is focused and seems as rational anti-cancer way for advanced cancer patients with low toxicity and moderate effectiveness. Herbal extractive medicines represent relatively low-toxicity and anti-cancer ability of multitargets by regulating tumor microenvironment and immune system [9-11]. According to clinical studies, while the late-stage patients who had been failure with second-line or later treatment, integrated palliative care that includes herbal extractive medicine was considered priority as a slavage treatment. Meanwhile, our previous laboratory studies have indicated that TGF-, EGF, VEGF, IL-10 cytokines expression and mico-vessel density could be downgraded by Senghuang capsule (SH) and Xianhe Baijiang capsule (XB) that extracted from Ginseng, Herba Agrimonia, Hairyvein and Arginine etc in 4T1 and CT26 cell lines model.
In this study, herbal extractive medicines were given to advanced lung cancer, hepatocellular cancer and unresectable pancreatic cancer patients, and quailty of life (QOL), toxicity and survival time were observed.

Methods

Patients
In total, 212 late-stage cancer patients including 13 unresectable pancreatic cancer patients, 31 hepatocellular cancer patients and 168 lung cancer patients, who were failure with first line treatment or could not tolerate toxicity treatments, were enrolled. All patients had radiographic and pathological diagnosis. The retrospective study had been approved by Ethics Committee of Chengdu Fuxing Hospital.
Drugs and treatment
Herbal extractive medicines, which approved by the Chinese Food and Drug Administration (CFDA), hyperthermia and argine were used. Survival time, quality of life (ECOG score) and toxicity were observed. The prescription was shown in Figure 1: Arginine 15ml, Senghuang capsule (SH) 1.80g and Xianhe Baijiang capsule (XB) 0.8g Qid and hyperthermia 41-41.5℃ Biw for four weeks as one cycle. Previous test by HPLC shows that the main ingredients of SH and XB consist of flavonoid, saponins and glucosides etc (Figure 1).
Data collection and safety & efficacy assessment
Prior therapies, patient’s condition and drugs’ dose, treatment information (i.e. current dose, dose adjustments), adverse events of LC, PC and HCC were recorded. ECOG score were documented at baseline and/or follow-up. Efficacy criteria included overall survival (OS) and quality of life (QOL). Adverse events were recorded and graded by National Cancer Institute Common Terminology Criteria version 3.0 (CTCAE 3.0).

Result

Patient characteristics and treatment
A total of 212 patients were enrolled including liver cancer (HCC), pancreatic cancer (PC) and lung cancer (LC) in late stage. Patients demographic and baseline characteristics was shown in Table 1. The median age was 58.0(PC), 62.7(LC) and 55.0(HCC) yearold, respectively, and the majority of patients were male (53.8% PC, 64.9% LC and 77.4% HCC). 4.7% (10/212) patients were tumornode- metastasis (TNM) stage at III, and 95.3% (202/212) patients were stage IV. According to the Eastern Cooperative Oncology Group (ECOG) score evaluation criteria, 92.3%(PC), 34.8%(HCC) and 36.3%(LC) were up to 2 score, and 7.7%(PC), 65.5%(HCC) and 63.7%(LC) were at 3-4 score, respectively. Treatment plan was shown in Table2 (Table 1,2).

Safety assessment
Safety data were reported in Table 3. Dyspepsia and skin injure were the most common adverse events. Dyspepsia was drug-related adverse events that was experienced 15.1 % (n=32) patients under grade 2; and no patients suffered over grade 3 on hematology as drug-related adverse events. Meanwhile, 10.9% patients (n=23) experienced skin injure events duo to hyperthermia treatment. No patients were excluded caused by severe side-effect (Table 3).

Efficacy
First, for168 lung cancer patients. The 6 months, 1-, 2- and 5-year survival time rates were 33.93%, 19.05%, 14.29% and 4.17% (Table 4), respectively. However, once the survival time was extended over 6 months (57/168), the average and median survival time were up to 29.98 and 14.80 months (Table 5); and the 1-, 2- and 5-year survival time rate were up to 56.14%, 42.11% and 12.28% (Table 4), respectively. The longest survival time reached to 134 months (Table 5). According to ECOG criteria, QOL in 59.6 % (34/57) patients were improved (Figure 2). Meanwhile, according to the data, such sub-group patients, who respond to herbal extractive medicine at least one month, could get better benefit from herbal extractive medicine based palliative care, and the drugrelated effectiveness would maintain. Second, for unresectable pancreatic cancer patients. The 3-, 6-, and 10-month survival rates were up to 92.3%, 46.2% and 30.8%, respectively (Table 4). The median and the average survival time were up to 5.1 and 6.5 months. The longest survival time was 16.7 months and patient still alive (Table 5). According to ECOG, QOL in 53.8 % (7/12) patients were improved (Figure 2). Third, for liver cancer patients. The 6-, 12-, 24 months and 5-year survival time rates were up to 45.16%, 29.03%, 12.90% and 3.23%, respectively (Table 4). The average and median survival time were 12.48 and 5.03 months, respectively, and the longest survival time was 84.17 months (Table 5). According to ECOG, QOL in 28.5 % (4/14) patients were improved and QOL in another 28.5 % (4/14) patients were stable (Tables 4,5) (Figure 2).

Discussion

This paper reported the patients who fail to on-going anti-cancer treatments. Approximately 30% of cancer patients who received first-line therapy need further subsequent treatment [12]. Tyrosine kinase inhibitor (TKI) such as Gefitinib, Solafinib or Laptinib have been shown to improve survival and symptoms in NSCLC and HCC. However, despite advances in pancreatic cancer therapy, the average survival rate at 5 years remains only 6% [13], especially for unresectable pancreatic cancer. Within these few treatment choices, adverse effects of recent drugs have further restricted patient clinical use [14], and their effectiveness for HCC and pancreatic cancer is not satisfactory. Nevertheless, herbal extractive medicines represent relatively low-toxicity and anti-cancer ability of multi-targets by regulating tumor microenvironment and immune system, which is preferred as second or later treatment and manage symptoms [15]. In clinical trials, it was proved by multidisciplinary teams, but the intensity of interventions varied considerably. Based on some clinical trials, integrated palliative care decreased overall mortality (HR 0.77; 95% CI 0.61 to 0.98), and short-term (1-3 months) effects of integrated palliative care on QOL was improved, but longer-term (6-12 months) effects on QOL was not improved [16-20].

Recently, once the definition of palliative care intervention characteristics was interpreted clearly, the more precise understanding of the impact of integrated palliative and oncology care on outcomes would approach [21]. Study by Temel et al, 151 NSCLC patients were delivered to early palliative care integrated with ongoing oncology care or to standard oncology care alone group in order to prove the importance of supportive care. Not only the patients who received early palliative care had better quality of life and less depression, but also were less likely to receive useless chemotherapy (33% vs. 54% in the standard chemo-treatment, p = 0.05). The patients, who received early palliative care, lived longer compared with standard treatment group (11.6 months vs. 8.9 months, P=0.02) [12,17]. Meanwhile, palliative care for pancreatic cancer were recommended in the course of illness and concurrently with active treatment [22, 23]. The use of Chinese herbal medicines (CHM) in symptom management for cancer palliative care is common in Chinese populations and clinical evidence on their effectiveness is already to be confirmed, and quality of life among cancer patients are affected. More than that, herbal medicines acted on the tumor and micro-environment though multi-targets [11]. Depend on our laboratory research, active ingredients, which were extracted from Ginseng, Herba Agrimonia, White Flower Patrinia Herb etc., consist of glycoside, saponin and flavone and could inhibit proliferation on HepG2, A549, 4T1 and CT26 cell lines, and decrease p-AKT and mTOR protein expression.

In this report, the late-stage patients received acceptable treatment result by using herbal extractive medicines as second or later treatment, which provide moderate effective and low-toxicity, and it could be considered as an as complementary and alternative medicine. In PC group, the median and the average survival time were 5.1 and 6.5 months; The 3-, 6-, and 10-month survival rates were 92.3%, 46.2%, and 30.8%, respectively. The longest survival time was 16.7 months and patient still alive. In HCC group, the average and median survival time were 12.5 and 5.0 months; The 3-, 6-, and 12-month survival time rates were 77.4%, 38.7%, and 29.0%, respectively. The longest survival time was 84.2 months. In LC group, the 6 months, 1-, 2- and 5-year survival time rates were 33.9%, 19.1%, 14.3% and 4.2%, respectively. Meanwhile, in lung cancer group, once the survival time was over 6 months, the average and median survival time were 29.98 and 14.8 months; and the 1-, 2- and 5-year survival time rates were up to 56.1%, 42.1% and 12.3%, respectively. Meanwhile, the most common drugrelated adverse event was gastrointestinal, especially dyspepsia, and just a low percentage of patients reported fatigue or diarrhea. No hematology side-effect, which was up to grade 2, was observed.

In summary, early involvement of palliative care can lead to less utilization of useless care caused by severe side-effects. Not only, in 2012, the American Society for Clinical Oncology (ASCO) has made a recommendation for ‘combined standard oncology care and palliative care consideration early in the course of illness for any patient with metastatic cancer and/or high symptom burden [24, 25], but also Chinese herbal medicine(CHM) may be considered as an add-on to conventional medicine in the management of pain, constipation, anorexia and fatigue in cancer patients. Thus, early palliative care was not ought to be recognized as a final method, and it was equally important to chemotherapy. This study makes an important contribution to the body of evidence on the efficacy of herbal extractive medicine that acted as an alternative method in late-stage lung, pancreatic and liver cancer which could be recommended as an initial treatment as second line or later treatment. Future RCTs should improve outcome measurement and report detailed safety outcomes.

Conclusion

CHM can be considered as complementary and alternative medicine that provide moderate effective and low toxicity for advanced cancer.

Acknowledgment

None.

Conflict of Interest

The authors declare that there is no conflict of interest.


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Tuesday, October 29, 2019

Iris Publishers-Open access Journal of Yoga, Physical Therapy and Rehabilitation | Utilities of Selected Yogic Practices In Health-Related Fitness Journal of Yoga Studies, The Journal of Yoga, Journal of Alternative and Complementary Medicine Yoga



Authored by Ganguly SK

The ultimate aim of all cultural practices of Āsanās is to produce psycho-physiological balance in various systems working in an individual. Proper organic function depends upon three important factors i.e.: a) Uninterrupted supply of nutrients to the tissues of the body through blood supply with healthy functioning of endocrine glands, b) Proper elimination of waste products and c) Better functioning of nervous system. Āsanās like Bhujagāsana, Shalabhāsana and Dhanurāsana etc. help a lot in this regard. Here the backward (Paschima) muscles are contracted and frontal muscles are stretched, while in Paschimotāna, the posterior muscles are wonderfully stretched. Uddiyāna, Nauli help the diaphragm to be raised thereby giving good massage from downward to the heart. Practices like Bhujagāsana, Salbhāsana, Dhanurāsana, alternatively exert pressure on heart. b) Healthy respiratory muscles with elasticity wherein no air cell should remain idle. c) Cleansed respiratory passage. In this context, Uddiyāna, Nauli and Kapālbhāti help a lot to build-up respiratory muscles powerful. Deep inspiration in Shalabhāsana and Dhanurāsana and deep expiration in Uddiyāna and Nauli help to build up elastic respiratory muscles while Kapālbhāti cleanses the respiratory passage forcefully. As far as the adrenals are concerned, this is made active through Bhujagāsana, Shalabhāsana, Dhanurāsana, Uddiyana and Nauli practices. The practices especially like Shirshāsana, Vipritakarani, and Sarvāngāsana work wonderfully for better venous return. These Yogic practices are not available in Physical education programmes or even in sports [1].
Keywords: Cultural practices; Health and fitness; Physical education; Yoga

Introduction

For the last one or two decayed, yoga in the form of Philosophy as well as Science is becoming very popular [2]. In this context, some good works in both the fields have been done in India and abroad in the past. In the past, in an International Yoga Conference held at Kaivalyadhām, various research workers also suggested the utilities of the same [3,4]. Therefore the purpose of this paper is to bring out a few rational of these practices from utility point of view.
The ultimate aim of all cultural practices of Āsanās is to produce psycho-physiological balance [5] in various systems working in an individual. The key point is on spinal cord movements [6] at all possible levels (i.e. forward, backward, sideways, twist/torsion) and finally having an impact on higher system.
All the meditative poses are having broad base and list resistance is given to the body against center of gravity and thereby controlling over BMR, Heart rate, pulse rate and thereby preparing a good background for Pranayama and higher practices.
Proper organic function depends upon three important factors i.e.: a) Uninterrupted supply of nutrients to the tissues of the body through blood supply with healthy functioning of endocrine glands, b) Proper elimination of west products and c) Better functioning of nervous system.
Movement of abdominal wall for 24 hours through proper inhalation and exhalation due to breathing has got an impact over regular massage over organs situated in the same. This is further regularized by the yogic poses like Uddiyāna, Nauli and Agnisāra and various Āsanas.
The diaphragm goes down and forward in each inhalation say about 16 to 18 times per minute by helping digestive organs. This can happen only when abdominal muscles are strong enough and elastic. If they are not, the end result will be indignation. Dyspeptic people found to be either very rigid in abdominal muscles or too weak.
Circulatory System has got the work of sending nourishment to the cell and tissues. The arteries, veins, capillaries and heart are the sole agent through which blood is circulated. Uddiyāna, Nauli help the diaphragm to be raised thereby giving good massage from downward to the heart.
Practices like Bhujagāsana, Salbhāsana, Dhanurāsana, alternatively exert pressure on heart. The first stage of Vipritakarani, Sarvāngāsana also give good positive (+) pressure to heart and thereby help in increasing the efficiency of the same.
Since the veins are the weakest of all and for twenty-four hours, they have to work to return the impure blood (Blue Blood) back to the heart, they have got lot of workload upon them. They are being helped by topsy-turvy practices mainly. As a result, an individual suffering from varicose vain gets lot of help and the pain cum swollen condition is reduced for they are externally helped [7].
Proteins, fats, sugar and salts are distributed to all the tissues once circulatory system is helped. At the respiratory muscles, the lungs also get better exercise when one does Bhujagāsana, Shalabhāsana, Dhanurāsana, and Mayurāsana. Thereby all the cells get oxygenated. To have this, three conditions are to be fulfilled: a) both the lungs should be in good condition and powerful. b) Healthy respiratory muscles with elasticity wherein no air cell should remain idle. c) Cleansed respiratory passage. In this context, Uddiyāna, Nauli and Kapālbhāti help a lot to build-up respiratory muscles powerful. Deep inspiration in Shalabhāsana and Dhanurāsana and deep expiration in Uddiyāna and Nauli help to build up elastic respiratory muscles while Kapālbhāti cleanses the respiratory passage forcefully. Nasal passage obstruction may be due to chronic nasal cataract and deviated septum, mucus etc. The first two cannot be dealt with, but mucus can be eliminated by various Kriyās like Kapālbhāti, Danda, Vastra Dhauti, Jala and Sutra Neti.
Although cases like adenoids, deviated septum, populous cannot be tacked but some Āsanās and other practices that deal with tonsils are Vipritakarani, Sarvāngāsana, Matsyāsana, Simhamudrā, and Jihvā-Bandha. The nasal catarrh also is benefited with these.
Even though, to a great extent Āsanās help in sending nourishment to each cell through the improvement of respiratory and circulatory enhancement, never the less, endocrine glands also become very much active. Proper glandular secretion is also necessary to have better health and fitness of an individual. Once any one of the glands is inactive, one has to face the serious problem in life. In this context Āsanas like Vipritakarani, Sarvāngāsana, Matsyāsana and mudras like Simha mudra and Jihvābandha help a lot to take care of the same so far thyroid gland [7] is concerned. While, pineal and pituitary glands are taken care of through Shirshāsana. As far as the adrenals are concerned, this is made active through Bhujagāsana, Shalabhāsana, Dhanurāsana, Uddiyāna and Nauli practices. To look after the male and female endocrine glands like testes and ovaries, Sarvāngāsana, Uddiyāna and Nauli work very efficaciously. So, the above yogic practices help maximally in maintaining the organic functions of the body.
The waste products (malas) as impurities are regularly are to be eliminated from the body as they create toxins. If the impurities (malas) remain inside the body, it becomes poisonous and one suffers from various illnesses. Herein, three important systems like respiratory, digestive, and excretory (elementary cannel) should be kept cleansed. In this context, practices like Jala Neti, Vastra, and Danda, Basti Kriyās are effective cleansing practices (dhauties) to take care of such systems.
Finally the nervous system is equally important to be taken care of to have efficiency in all walks of life and individual. The practices especially like Shirshāsana, Vipritakarani, and Sarvāngāsana work wonderfully for better venous return. These Yogic practices are not available in Physical education programme or even in sports [1].
This is not exhaustive utility of yogic practices as such. The selected yogic practices as a whole could be utilized very effectively in our day to day lives [2,7], for it proves beyond doubts that these yogic practices[8] satisfy almost all the conditions upon which health and fitness lies as proved in a recent study[3].
Lastly, one should not forget at all the old proverb of western and eastern concept saying “A healthy mind in healthy body” and “SariraMadhyamKhalu Dharma Sadhanam”. Ultimately, one should not forget that Physical Educationist and Sports personnel [1] are no other than a human being and whose needs are more so far health and fitness are concerned. In fact in war and peace, fitness wins.

Acknowledgment

None

Conflict of Interest

The authors made no disclosures.


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Iris Publishers-Open access Journal of Yoga, Physical Therapy and Rehabilitation | A Brief Introduction of Qigong Dynamic Qigong: Tai Chi



Authored by Jeff Chui

What is Qigong?

Our body has a meridian network where an energy called “Qi” circulates. The flow of Qi correlates to our health and well being. Qigong is a methodology for promoting smooth flow and maintaining a balance of Qi within the meridian network.
But why do we care about Qi flow? As there are strong correlation between Qi flow in the meridians and healthiness of our internal organs, we can practice Qigong as a self-healing, natural therapy to health issues and a preventive measure.
Qigong could generally be categorized into two major groups, static and dynamic. Static Qigong’s characteristics are nearly motionless, maintain a posture such as sitting or standing for an extended period of time. Dynamic Qigong, on the other hand, consists of continuous movements, emphasize on the change of postures and movements. As in the theory of Yin Yang (there is Yin within Yang, and Yang within Yin, see Figure 1), there is no absolute Static nor Dynamic Qigong as Static Qigong has some motions and Dynamic Qigong has its quiet time. Tai Chi and Yoga are good examples of Dynamic Qigong, while Tai Chi is more dynamic relative to yoga.
Tai Chi can be used as a daily exercise to enhance body balancing and tranquillizing the mind. However, to maximise the benefits, it should be learnt and advanced through 6 stages, namely form, posture, mindfulness, jin (an internal force), Qi, and spiritual:
a. Form: Perform the Tai Chi movements
b. Posture: Perform the form at precise positioning and in continuous and body synchronization
c. Mindfulness: Highly concentrate in performing the movements but at ease; instinctively
d. Jin: The movements are smooth and effortless, yet the body is filled with an internal force
e. Qi: The mind commands the Qi to flow, and Qi drives the body as each movement is performed
f. Spiritual: The previous five levels are fused together in every movement
While each stage is more advanced than the previous stage, the previous stage is fundamental to the next stage, especially stage 6, spiritual cannot be achieved without the solid foundation of each of the first five stages. In fact, Qi flow is already enhanced even at stage 1, making Tai Chi a great form of Dynamic Qigong.
If Tai Chi has it all, why bother with Static Qigong? Although Tai Chi is suitable for all age groups, it does require efforts to memorize the movements, such that one can reach the gating stage which is mindfulness. Since Static Qigong usually involves a lot less movements and posture requirements, it is easier for one to reach the mindfulness stage and advance directly into the Qi stage.
None
The authors made no disclosures.



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Saturday, October 26, 2019

Iris Publishers-Open access Journal of Material Science | A Simple Equation Results in Decades of Technical Fun


Authored by Ronald C Lasky


Decades ago, when I was getting my PhD, I needed to calculate the density of a mixture of two polymers. I was tempted to use equation 1 below:
Where x is the mass fraction of polymer (or metal for a metal alloy), y the mass fraction of polymer 2, rho the respective densities and rho the total polymer or alloy density
The derivation is in the appendix. Others have derived this equation before, as it is in some metallurgy texts.
Little did I know at the time that this equation would yield decades of “confrontation” and technical fun. Right after deriving this equation, some of my materials science grad student friends heard about it and asked for the equation. I suggested they derive it themselves and was a bit surprised that they had trouble doing it and sheepishly asked for my help in the derivation.
Years later, I began working in materials for electronic assembly, mostly solder alloys. About 15 years ago, I began blogging on topics in this materials field. I am still an active bloggeri today.
Shortly after beginning my blogging efforts, I posted on why equation 1 is incorrect and equation 2 is right. Thus, began over a decade of queries to my blog about equation 2. An example follows (with names changed):Dr. Lasky,
My name is John Smith, a PhD metallurgist. I read with interest your article on calculating densities of alloys. Surely your formula:
can’t be correct. I have been at ACME metals for over 30 years and have always used:
Please tell me it is not wrong!
Best, John Smith
Unfortunately, for Dr. Smith, he has been wrong for 30 years.
I then developed an Excel® spreadsheetii to perform density calculations. I have had 100s of requests for the spreadsheet over the last decade.
As time went on, I was asked to verify the wet gold techniqueiii. This technique is used to estimate gold content in jewelry scrap and gold ores. One thing that scares me is that it can only be used in a binary system (i.e. gold and one other metal or constituent.) I believe many users don’t know this fact.
I continue to be asked to verify gold content formulas as a function of density and have incorporated much of this work into my classes at Dartmouth. I expect to have similar adventures in the future.
Appendix: Derivation of the Equation
irispublishers-openaccess-modern-concepts-material-science
Dividing equation 1 by mt ,
None.
No conflict of interest.


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Iris Publishers-Open access Journal of Material Science| Can Thin-Film Technology Help to Realize the Einstein Gravity Quantum Computer?



Authored by Norbert Schwarzer

After it became clear that Quantum Computers are more powerful than originally thought [1], the question popped up whether one could find the most fundamental form of a Turing machine based on Quantum Theory. Doing this job in a very comprehensive manner, we found that the deepest layer for the Quantum Computer was not to be found inside the theoretical apparatus of Quantum Theory. Surprising as this may be, it is the General Theory of Relativity which “contained it all”. We found that an extremely simple solution of the Einstein-Field-Equations, using pairwise dimensional entanglement, sports the principle structural elements of computers [2]. We will derive these structural elements and show that the classical computer technology of today and even the quantum computers are just degenerated derivatives of this general solution. In this short paper we will discuss thin-film technology- and smart material-options potentially helping us to one day realize the general computer concept. As often spin is seen as THE one possibility to realize Quantum Computers, we will try to find a metric understanding of the concept of spin.

Introduction

In order to keep this paper as brief as possible we only introduce the essentials. These essentials are a set of new solutions to the Einstein-Field-Equations as given in [2-34]. Among these solutions, we also found candidates with the potential to construct Turing or Turing-like machines [35] having special bits apparently even more powerful than quantum bits.
In [34] we gave a time dependent (oscillating) solution, which represented a metric satisfying the Einstein-Field-Equations [36,37] for the case of an arbitrary 2-EQ-bit (EQ=Einstein Quantum) processor. Here we intend to investigate these solutions with respect to possible extensions regarding more bits plus timidly start to explore the question of storage and machine design in connection with the quantum property named spin.

How to Quantize Solutions of the Einstein-Field-Equations

As the introduction to the method of quantizing metric solutions of the Einstein-Field-Equations is quite lengthy and was already presented in a variety of previous papers [2-34], we refrain from presenting it here again. Instead, we will only give a brief recipe:
1. We consider space as an ensemble of properties.
2. These properties could just be degrees of freedom and thus, dimensions, which are subjected to a Hamilton extremal principle.
3. This leads to the Einstein-Hilbert-Action [36] and subsequently to the Einstein-Field-Equations [36,37].
4. Time seems to take a special place among the properties as it is not such a property itself but consists of all other properties’ internal changes and variations. Applying the Einstein-Field-Equations on the internal degrees of freedom of each single property as a one-dimensional space (c.f. [14]), gives exactly 6 solutions [17] among which we always also find oscillations. These internal periodic processes (changes) inside each property or dimension are realized as time from an external observer… time, which itself forces other properties to change. Thus, starting as an internal property (solution) within each dimension, time not only is change, but also brings change about. Apparently, time is the most fractal and self-similar thing there is in this universe.
5. Now, however, we have the interesting situation that solutions to the Einstein-Field-Equations are not necessarily unique. Derived from the Einstein-Hilbert-Action as an extremal principle, the starting quantity is the so-called Ricci scalar R, being the essential kernel of this action. This results in a metric solution to the Einstein-Field-Equations, being subsequently derived from the Einstein-Hilbert-Action. Most interestingly, there are also infinitely many solutions to just one given Ricci kernel. Just as an example, one might take the flat Minkowski space and the Schwarzschild vacuum metric [38]. Both have a vanishing Ricci scalar R=0, but while the first describes empty space, the second, even though being a vacuum solution, contains a gravitational “object” of spherical symmetry. And yes, this all comes out from a variational kernel of R=0. Thus, so our conclusion, there seem to be quite some degrees of freedom regarding the choice of metric solutions to just one Ricci scalar curvature.
6. Tickling metric solutions with respect to this degree of freedom, which is to say to perform a variation (or transformation) of metric solutions, thereby treating the Ricci scalar as a conserved quantity, gives us classical quantum equations and thus Quantum Theory.
Essentially one finds Quantum Gravity as transformations to metrics solving the Einstein-Field-Equations:


Here we have: Rαβ,Tαβ the Ricci- and the energy momentum tensor, respectively, while the parameters Λ and κ are constants (usually called cosmological and coupling constant, respectively). These are the well-known Einstein-Field-Equations in n dimensions with the indices α and β running from 0 to n-1. The theory behind is called “General Theory of Relativity”.
Thereby we can use external or internal degrees of freedom. While in most of our previous papers (e.g. [33] as this is most compact) we concentrated on external or wrapper-like transformations of the kind:


we also introduced inner or Killing-like approaches in [39]. Most interestingly, these inner Quantum Gravity transformations led to the Dirac equation [40].
In conclusion we might state that Quantum Theory is just the inner degree or fluctuation of metric solutions to the Einstein- Field-Equations.
The interested reader will find a compact mathematical presentation of the above recipe in [33].

The 2-Bit EQ or Einstein Quantum Computer

It is a common misinterpretation of the original Turing work [35] that many people assume Turing has suggested a digital machine. In fact, his approach contained a computer machine with an arbitrary real basis, but Turing considered the use of integer numbers to be the most appropriate way to realize his machine and so he suggested the digital form. In principle, however, his concept was not necessarily restricted to a digital basis.
As we found that the Einstein-Field-Equations are the most principle building blocks of this universe, we want to find solutions to these equations, which – at least in theory – allow us to build a computer. It is obvious that such a system requires a circuit time, governing the whole system and two additional properties allowing for storage and operations.
The corresponding evaluation was already performed elsewhere [2,34,41]. For convenience we here repeat it briefly.
By applying a metric approach of the kind:


we will find a general solution to the Einstein-Field-Equations [1, 3] with the function:


Thereby Λ denotes the cosmological constant. Please note the matter and anti-matter character of our solution (4). The functions gx and gy are arbitrary and could be used for operations/data of any arbitrary form. In order to assure digital outcomes to the metric components g11 and g22, standing for the second and the third diagonal metric component, respectively, we construct Fourier series of the kind:


We see that the system constructed above has everything a most simple 2-bit “processor” requires. It has the necessary two bits and it has a periodic function defining a cycle time. What we also need is a way to store information. Applying the Turing approach [35], we might just couple in certain add-on dimensions playing the role of these storages, or, if using the Turing picture, playing the role of the tape of our EQ-Turing machine (EQ=Einstein Quantum). A simple extension of the metric (3) of the form:


might help us to solve the problem for at least one storage process by entangling the coordinates x-ξ and x-η. A second set of solutions can be constructed via the following approach:


and would bring the same result in a slightly variated form (read and write options).
We recognize the application of the pairwise coupling or entanglement of dimensions as elaborated in [42]. Substituting ξ=xx and η=yy we can directly obtain the solutions from [34] with the following sub-metric of the components 1-4:


The total metric shall be given then either as:


or (careful with the constant H and the function H[t]):


With the help of the results of [43,44] we can solve the subsequent Einstein-Field-Equations and find:


While in the case of H[t] and an assumed gt[t]=t we obtain a bell shaped function, meaning that the whole system appears and disappears after a while (it only virtually exists), we now have a stable oscillation in the case h[t] (Figure 1).

Things change dramatically in the case Λ=0, where the Einstein- Field-Equations require the following rather different solutions for the cycle-time functions h[t] and H[t], reading:


In addition, we have the functions f, g, F and G as before plus the boundary condition for the constants A, B and ci as follows (Figure 2):


This time the approach gt[t]=t does not lead to oscillations for h[t] but still we can achieve time-periodic behavior via H[t] and gt[t]=i*t.
Using the results from above it is easy to construct the metrics for higher bit-systems. For instance, the total metric for an 8-bit case would have to contain 17 dimensions and could generally be given as:


We have the two options for pairwise coupling (entanglement), namely:


By the structure given in (14), it can easily be seen how the extension to any number of bits can be achieved.

The Metric Understanding of Spin

Thin film technology has allowed to create so-called quantum dot structures, sporting typical quantum properties in an applicable, which is to say steerable manner. As it is widely assumed that the realization of a Quantum Computer is achievable by using the quantum property spin, we require an Einstein-based, which is to say, metric understanding of this property.
Starting with the following metric:


and demanding a vanishing cosmological constant


we have shown in [45] that the resulting Ricci scalar R* of the transformed metric using recipe (2) and the corresponding 4D wrapper-function F [f=f [t, r, ϑ, φ]] =(C1+f) ² reads:


Now we substitute as follows in (19):


Applying the separation approach f[t,r,ϑ,φ]=g[t]*h[r]*Y[ϑ]*Z[φ] with the previously used separation parameters Ct and m (compare for the sub-section ”Flat Space Situation” in [33]) in (19) gives us the following immediate solution for g[t] and Z[φ]:


The two remaining differential equations can be constructed as follows:


While the first equation of the two gives the usual solution with the Legendre polynomials, as also known from the Schrödinger hydrogen solution [46] only in slightly generalized manner (watch the asymmetry-parameter B):


we have a rather non-Schrödinger-like solution with respect to the radius coordinate in the case of R*=0:


Regarding the angular functions within f […] we might assume that, just as known from the Schrödinger hydrogen problem, we have the conditions L= 0,1,2, 3, … and -L ≤ B*m ≤ L. However, it was shown in [33,45] that we also have options for singularity free solutions with L= {1/2,3/2,5/2, …}. We realize that our solution has no main quantum number as the classical Schrödinger solution does. However, it was shown that such a number appears with the introduction of a potential V[r]~1/r (the classical Schrödinger way), the breaking of symmetry ([33] or appendix of [45]) or the assumption of a boundary in r (e.g. [33]). As we are here only interested in the half-spin solutions, we simply apply the classical Schrödinger way and start with an approach for R* as follows:


Setting this into the last line of (20) gives:


Now the classical Schrödinger wave function [46]:


directly solves our Quantum Gravity equation (28) for static cases where f does not depend on t.
The constant a0 is denoting the Bohr radius with (me=electron rest mass, ε0=permittivity of free space, Qe=elementary charge):


The functions P, L and Y denote the associated Legendre function, the Laguerre polynomials and the spherical harmonics, respectively.
The extension to time-dependent f according to (28) is simple. However, in order to avoid too many parameters and work out the connection to the classical Schrödinger evaluation, we set H=A=B=D=1. By using the results from above we can reproduce the Schrödinger hydrogen problem from (28) being changed to:


Thereby we have introduced the term irispublishers-openaccess-modern-concepts-material-science(reduced Planck constant squared irispublishers-openaccess-modern-concepts-material-science divided by mass (M) in order to truly mirror the classical Schrödinger equation. Multiplying with M would give us:


and connects the mass M with the curvature terms R6 and the momentum.
Comparison of (31) with the Schrödinger derivation (e.g. [46], pp. 155) and if R60 is a constant gives us:


Using the result for g[t] from above, which is to say:


we can now rewrite (33) as follows:


and thus, get the classical radial Schrödinger solution for the radial part of f […]:


Regarding the conditions for the quantum numbers n, l and m, we not only have the usual:


but also found suitable solutions for the half-spin forms as discussed above and derived in the appendix. The corresponding main quantum numbers for half-spin l-numbers with l=1/2, 3/2, … are simply (just as before with the integers) n=l+1=3/2,5/2,7/2, l….
It should explicitly be noted, however, that the usual spherical harmonics are inapplicable in cases of half-spin. For {n, l, m} = {1/2, 3/2, 5/2, 7/2, …] the wave function (36) has to be adapted as follows:


Thereby it was elaborated in [45] that in fact the sin- and the cos-functions seem to make the Pauli exclusion (s. [47]) and not the “+” and “-“ of the m. However, in order to have the usual Fermionic statistic we can simply define as follows:


As discussed above and derived in [33] plus the appendix in [45], the resolution of the degeneration with respect to half-spin requires a break of the symmetry, which we achieved by introducing elliptical geometry instead of the spherical one.
Assuming an omnipresent constant curvature R60 does not seem to make much sense in our current system and thus, we should set R60=0. Doing the same with the curvature parameter R62 just gives us the usual condition for the spherical harmonics, namely ω2 = L(1+ L) = l2 +1.
Thus, we result in:


This metrically derived “hydrogen atom”, which also has half-spin solutions, was intensively discussed in [45]. Here we concentrate on l=1/2 situations, which – so the immediate association when illustrating the corresponding spatial distortion – not only directly explain the Pauli exclusion principle but also allow for a structural understanding of the half-spin solutions.
Only in order to keep things familiar and potentially compare with the classical integer hydrogen states (40), we keep the normalization and the scale of the Bohr radius a0. One might perhaps call the resulting objects “half-spin hydrogen atoms”. With only one exception (Figure 5) we start with the general setting of m>0 ( → Z[φ]=cos[m*φ]). It can easily be seen with the simplest half-spin states (n=3/3, l=1/2 and |m|=1/2) as presented in Figures 3&4, that the gross of deformed space-time is to be found on the right hand side of the x=0-plane. Now choosing n=3/3, l=1/2 and m=-1/2 and applying the statistic rule defined in (39), leading to Z[φ]=sin[m*φ], gives us a concentration of deformed space-time on the other side of the x=0-plane (Figure 5). It appears intuitive to assume that the combination of objects with deformation maxima on the left and right (anti-parallel spin) is easier than the combination of objects having the maximum deformations on the same sides of the x=0-plane (parallel spin combination). We might see this as the geometric manifestation of the Pauli exclusion principle [47].


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